PMID- 17942423
OWN - NLM
STAT- MEDLINE
DCOM- 20080118
LR  - 20211020
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 35
IP  - 22
DP  - 2007
TI  - Caloric restriction and genomic stability.
PG  - 7485-96
AB  - Caloric restriction (CR) reduces the incidence and progression of spontaneous and 
      induced tumors in laboratory rodents while increasing mean and maximum life 
      spans. It has been suggested that CR extends longevity and reduces age-related 
      pathologies by reducing the levels of DNA damage and mutations that accumulate 
      with age. This hypothesis is attractive because the integrity of the genome is 
      essential to a cell/organism and because it is supported by observations that 
      both cancer and immunological defects, which increase significantly with age and 
      are delayed by CR, are associated with changes in DNA damage and/or DNA repair. 
      Over the last three decades, numerous laboratories have examined the effects of 
      CR on the integrity of the genome and the ability of cells to repair DNA. The 
      majority of studies performed indicate that the age-related increase in oxidative 
      damage to DNA is significantly reduced by CR. Early studies suggest that CR 
      reduces DNA damage by enhancing DNA repair. With the advent of genomic technology 
      and our increased understanding of specific repair pathways, CR has been shown to 
      have a significant effect on major DNA repair pathways, such as NER, BER and 
      double-strand break repair.
FAU - Heydari, Ahmad R
AU  - Heydari AR
AD  - Department of Nutrition and Food Science, Wayne State University, Detroit, MI 
      48202, USA.
FAU - Unnikrishnan, Archana
AU  - Unnikrishnan A
FAU - Lucente, Lisa Ventrella
AU  - Lucente LV
FAU - Richardson, Arlan
AU  - Richardson A
LA  - eng
GR  - P01 AG019316/AG/NIA NIH HHS/United States
GR  - P01-AG19316/AG/NIA NIH HHS/United States
GR  - P30 AG013319/AG/NIA NIH HHS/United States
GR  - 1P30-AG13319/AG/NIA NIH HHS/United States
GR  - R01 CA121298/CA/NCI NIH HHS/United States
GR  - R37 AG26577/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20071016
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
SB  - IM
MH  - Aging/genetics
MH  - Animals
MH  - *Caloric Restriction
MH  - DNA Damage
MH  - *DNA Repair
MH  - *Genomic Instability
MH  - Mice
MH  - Rats
PMC - PMC2190719
EDAT- 2007/10/19 09:00
MHDA- 2008/01/19 09:00
PMCR- 2007/10/16
CRDT- 2007/10/19 09:00
PHST- 2007/10/19 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/10/19 09:00 [entrez]
PHST- 2007/10/16 00:00 [pmc-release]
AID - gkm860 [pii]
AID - 10.1093/nar/gkm860 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2007;35(22):7485-96. doi: 10.1093/nar/gkm860. Epub 2007 Oct 
      16.