PMID- 17943082
OWN - NLM
STAT- MEDLINE
DCOM- 20080422
LR  - 20151119
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 73
IP  - 3
DP  - 2008 Feb
TI  - The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the 
      urine predicts renal prognosis in IgA nephropathy.
PG  - 327-33
AB  - The production of cytokines by resident and non-resident renal cells during 
      immunoglobulin A nephropathy (IgAN) plays a key role in the progression of renal 
      damage. The aim of this study was to determine if measurements of urinary 
      epidermal growth factor (EGF) and monocyte chemotactic peptide-1 (MCP-1), at the 
      time of renal biopsy, were a predictor of end-stage renal disease (ESRD) in a 
      cohort of 132 patients with biopsy-proven IgAN. Outcome measures were a doubling 
      of the baseline serum creatinine (sCr) and/or ESRD. Patients with ratios of 
      EGF/MCP-1 in the lowest tertile had a significant decline in renal survival, 
      while patients in the highest tertile maintained 100% renal survival at 48 and 84 
      months of follow-up. Multivariate Cox's regression analysis showed that the urine 
      EGF/MCP-1 ratio was an independent prognostic factor and indirectly correlated 
      with the combined outcome. The predictive value was also measured by the area 
      under the receiver operating characteristic curve (ROC). The area of the 
      EGF/MCP-1 ratio was significantly higher than that of EGF or MCP-1 alone, 
      histologic grade, creatinine clearance, or proteinuria. Our study suggests that 
      the urinary EGF/MCP-1 ratio may be used as a prognostic marker of ESRD for 
      patients with IgAN.
FAU - Torres, D D
AU  - Torres DD
AD  - Renal, Dialysis and Transplantation Unit, Department of Emergency and Organ 
      Transplantation, University of Bari, Bari, Italy.
FAU - Rossini, M
AU  - Rossini M
FAU - Manno, C
AU  - Manno C
FAU - Mattace-Raso, F
AU  - Mattace-Raso F
FAU - D'Altri, C
AU  - D'Altri C
FAU - Ranieri, E
AU  - Ranieri E
FAU - Pontrelli, P
AU  - Pontrelli P
FAU - Grandaliano, G
AU  - Grandaliano G
FAU - Gesualdo, L
AU  - Gesualdo L
FAU - Schena, F P
AU  - Schena FP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071017
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
CIN - Kidney Int. 2008 Feb;73(3):249-51. PMID: 18195693
CIN - Nat Clin Pract Nephrol. 2008 Apr;4(4):184-5. PMID: 18268524
MH  - Adult
MH  - Biomarkers/urine
MH  - Biopsy
MH  - Chemokine CCL2/*urine
MH  - Disease Progression
MH  - Epidermal Growth Factor/*urine
MH  - Female
MH  - Glomerulonephritis, IGA/pathology/*urine
MH  - Humans
MH  - Kidney/pathology
MH  - Male
MH  - Prognosis
MH  - Prospective Studies
EDAT- 2007/10/19 09:00
MHDA- 2008/04/23 09:00
CRDT- 2007/10/19 09:00
PHST- 2007/10/19 09:00 [pubmed]
PHST- 2008/04/23 09:00 [medline]
PHST- 2007/10/19 09:00 [entrez]
AID - S0085-2538(15)52971-2 [pii]
AID - 10.1038/sj.ki.5002621 [doi]
PST - ppublish
SO  - Kidney Int. 2008 Feb;73(3):327-33. doi: 10.1038/sj.ki.5002621. Epub 2007 Oct 17.