PMID- 17945079
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20071019
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 19
IP  - 10
DP  - 2007 Oct
TI  - [Protective effects of electric stimulation of vagus nerve on acute lung injury 
      in rat with sepsis].
PG  - 593-5
AB  - OBJECTIVE: To investigate the protective effect of stimulation of vagus nerve on 
      acute lung injury in rat with sepsis. METHODS: Sepsis was reproduced by cecal 
      ligation and puncture (CLP). Forty male Sprague-Dawley (SD) rats were randomly 
      divided into 4 groups (each n=10): SHAM group received performed sham surgery. In 
      CLP group, CLP was performed. In vagotomy (VGX) group, rats were subjected to 
      bilateral cervical VGX following CLP. In vagus stimulation (STM) group, rats were 
      subjected to bilateral cervical VGX after CLP and the efferent end of the left 
      vagus nerve was stimulated with electric current. The animals were sacrificed at 
      18 hours after production. Tumor necrosis factor-alpha (TNF-alpha) level in blood 
      was detected, arterial blood lactic acid concentration,pH, partial pressure of 
      oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial 
      blood (PaCO2), base excess (BE) and lung wet/drying (W/D) ratio were determined. 
      The histopathology and ultra-microstructure of the lung were observed. RESULTS: 
      The TNF-alpha and lactic acid concentrations, PaCO2 and W/D ratio were all 
      increased, and pH, PaO2, BE all lowered in CLP group and VGX group compared with 
      those of SHAM group (P<0.05 or P<0.01). Compared with CLP group, TNF-alpha, 
      lactic acid concentration,PaCO2,W/D ratio in STM group were decreased obviously, 
      and pH, PaO2 and BE were all increased (P<0.05 or P<0.01). The lung tissue 
      pathology and ultra-microstructure changes indicated that lung injury was severe 
      in CLP group than in SHAM group and was ameliorated in STM group compared with 
      that of CLP group and VGX group. CONCLUSION: The results suggest that direct 
      electrical stimulation of the efferent end of vagus nerve can protect lung 
      against injury induced by sepsis in rat.
FAU - Wang, Li
AU  - Wang L
AD  - Intensive Care Unit, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei, 
      China.
FAU - Li, Jian-guo
AU  - Li JG
FAU - Jia, Bao-hui
AU  - Jia BH
FAU - Wu, Yuan-bo
AU  - Wu YB
FAU - Zhou, Qing
AU  - Zhou Q
FAU - Du, Zhao-hui
AU  - Du ZH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute Lung Injury/etiology/*prevention & control
MH  - Animals
MH  - Disease Models, Animal
MH  - *Electric Stimulation
MH  - Lung/pathology
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sepsis/blood/*complications/pathology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - *Vagus Nerve
EDAT- 2007/10/20 09:00
MHDA- 2009/10/09 06:00
CRDT- 2007/10/20 09:00
PHST- 2007/10/20 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
PHST- 2007/10/20 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Oct;19(10):593-5.