PMID- 17945166
OWN - NLM
STAT- MEDLINE
DCOM- 20090424
LR  - 20221207
IS  - 1673-8527 (Print)
IS  - 1673-8527 (Linking)
VI  - 34
IP  - 10
DP  - 2007 Oct
TI  - Adiponectin gene variation -4522C/T is associated with type 2 diabetic obesity 
      and insulin resistance in Chinese.
PG  - 877-84
AB  - The authors investigated the possible association of -4522C/T variation of 
      adiponectin gene with coronary heart disease (CHD) and type 2 diabetes mellitus 
      (T2DM). Genotyping of SNP -4522C/T in 304 patients with CHD, 389 patients with 
      T2DM, and 405 age and sex-matched healthy control subjects was carried out by 
      means of PCR-RFLP approach. No significant difference in the genotype or allele 
      frequencies was found, either between patients with CHD and control subjects, or 
      between patients with T2DM and control subjects. However, in the subgroup 
      analysis, an association of the T/T genotype and T allele with type 2 diabetes 
      combined with obesity (BMI > or = 25 kg/m(2)) was found (P = 0.014 and P = 0.034, 
      respectively). Also the homeostasis model assessment of insulin resistance 
      (HOMA-IR) in T2DM patients with T/T genotype was significantly higher than that 
      in T2DM patients carrying C allele (P = 0.0069). The authors' findings for the 
      first time demonstrated that SNP -4522 in the adiponectin gene was associated 
      with T2DM that combined with obesity and higher insulin resistance index in 
      patients with T2DM. This indicated that the variation might associate with an 
      increased susceptibility to type 2 diabetic obesity and insulin resistance. But 
      -4522C/T polymorphism did not contribute to the susceptibility of CHD.
FAU - Liu, Hekun
AU  - Liu H
AD  - Department of Medical Genetics, West China Hospital, Sichuan University, and 
      Division of Human Morbid Genomics, State Key Laboratory of Biotherapy of Human 
      Diseases, Chengdu 610041, China.
FAU - Chen, Suyun
AU  - Chen S
FAU - Zhang, Sizhong
AU  - Zhang S
FAU - Xiao, Cuiying
AU  - Xiao C
FAU - Ren, Yan
AU  - Ren Y
FAU - Tian, Haoming
AU  - Tian H
FAU - Li, Xuefei
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Genet Genomics
JT  - Journal of genetics and genomics = Yi chuan xue bao
JID - 101304616
RN  - 0 (Adiponectin)
RN  - 0 (Lipids)
RN  - 0 (RNA Splice Sites)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Coronary Disease/blood/complications/genetics
MH  - Databases, Genetic
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - RNA Splice Sites
EDAT- 2007/10/20 09:00
MHDA- 2009/04/25 09:00
CRDT- 2007/10/20 09:00
PHST- 2007/02/09 00:00 [received]
PHST- 2007/03/30 00:00 [accepted]
PHST- 2007/10/20 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
PHST- 2007/10/20 09:00 [entrez]
AID - S1673-8527(07)60099-X [pii]
AID - 10.1016/S1673-8527(07)60099-X [doi]
PST - ppublish
SO  - J Genet Genomics. 2007 Oct;34(10):877-84. doi: 10.1016/S1673-8527(07)60099-X.