PMID- 17945874
OWN - NLM
STAT- MEDLINE
DCOM- 20080310
LR  - 20200609
IS  - 1557-170X (Print)
IS  - 1557-170X (Linking)
VI  - 2006
DP  - 2006
TI  - Ordinary differential equation models for ethanol pharmacokinetic based on 
      anatomy and physiology.
PG  - 5033-6
AB  - Physiologically-based pharmacokinetic (PBPK) models have been used to describe 
      the distribution and elimination characteristics of intravenous ethanol 
      administration. Further, these models have been used to estimate the ethanol 
      infusion profile required to prescribe a specific breath ethanol concentration 
      time course in a specific human being, providing a platform upon which other 
      pharmacokinetic and pharmacodynamic investigations are based. In these PBPK 
      models, the equivalence of two different peripheral tissue models are shown and 
      issues concerning the mass flow into the liver in comparison with ethanol 
      metabolism in the liver are explained.
FAU - Han, Jae-Joon
AU  - Han JJ
AD  - School of Electrical & Computer Engineering, Purdue University, West Lafayette, 
      IN 47907-2035, USA.
FAU - Plawecki, Martin H
AU  - Plawecki MH
FAU - Doerschuk, Peter C
AU  - Doerschuk PC
FAU - Ramchandani, Vijay A
AU  - Ramchandani VA
FAU - O'Connor, Sean
AU  - O'Connor S
LA  - eng
GR  - N01AA23102/AA/NIAAA NIH HHS/United States
GR  - P60 AA07611-16-17/AA/NIAAA NIH HHS/United States
GR  - R01 AA12555-05/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Conf Proc IEEE Eng Med Biol Soc
JT  - Conference proceedings : ... Annual International Conference of the IEEE 
      Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and 
      Biology Society. Annual Conference
JID - 101243413
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Algorithms
MH  - Chemistry, Pharmaceutical/methods
MH  - Computer Simulation
MH  - Ethanol/chemistry/metabolism/*pharmacokinetics
MH  - Humans
MH  - Kinetics
MH  - Liver/drug effects
MH  - Models, Theoretical
MH  - Respiration/*drug effects
MH  - Risk Assessment
MH  - Tissue Distribution
MH  - Toxicology/*methods
EDAT- 2007/10/20 09:00
MHDA- 2008/03/11 09:00
CRDT- 2007/10/20 09:00
PHST- 2007/10/20 09:00 [pubmed]
PHST- 2008/03/11 09:00 [medline]
PHST- 2007/10/20 09:00 [entrez]
AID - 10.1109/IEMBS.2006.259570 [doi]
PST - ppublish
SO  - Conf Proc IEEE Eng Med Biol Soc. 2006;2006:5033-6. doi: 
      10.1109/IEMBS.2006.259570.