PMID- 17947701
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 179
IP  - 9
DP  - 2007 Nov 1
TI  - The role of dendritic cells in the development of acute dextran sulfate sodium 
      colitis.
PG  - 6255-62
AB  - Dendritic cells (DCs) are essential mediators of the host immune response to 
      surrounding microbes. In this study, we investigate the role of DCs in the 
      pathogenesis of a widely used colitis model, dextran sulfate sodium-induced 
      colitis. The effect of dextran sulfate sodium on the production of 
      proinflammatory cytokines and chemokines by bone marrow-derived DCs (BM-DCs) was 
      analyzed. BM-DCs were adoptively transferred into C57BL/6 mice or DCs were 
      ablated using transgenic CD11c-DTR/GFP mice before treatment with 5% dextran 
      sulfate sodium in drinking water. We found that dextran sulfate sodium induced 
      production of proinflammatory cytokines (IL-12 and TNF-alpha) and chemokines (KC, 
      MIP-1alpha, MIP-2, and MCP-1) by DCs. Adoptive transfer of BM-DCs exacerbated 
      dextran sulfate sodium colitis while ablation of DCs attenuated the colitis. We 
      conclude that DCs are critical in the development of acute dextran sulfate sodium 
      colitis and may serve a key role in immune balance of the gut mucosa.
FAU - Berndt, Bradford E
AU  - Berndt BE
AD  - Gastroenterology Division, Department of Internal Medicine.
FAU - Zhang, Min
AU  - Zhang M
FAU - Chen, Gwo-Hsiao
AU  - Chen GH
FAU - Huffnagle, Gary B
AU  - Huffnagle GB
FAU - Kao, John Y
AU  - Kao JY
LA  - eng
GR  - DK-34533/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (CD11c Antigen)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Diphtheria Toxin)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Acute Disease
MH  - Adoptive Transfer
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - Bone Marrow Transplantation
MH  - CD11c Antigen/genetics/metabolism
MH  - Cell Differentiation/immunology
MH  - Chemokines/biosynthesis
MH  - Colitis/chemically induced/*immunology/metabolism/*pathology
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/cytology/*drug effects/*immunology/metabolism
MH  - Dextran Sulfate/*pharmacology
MH  - Diphtheria Toxin/pharmacology
MH  - Female
MH  - Intestinal Mucosa/metabolism
MH  - Lymph Nodes/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neutrophils/drug effects
MH  - Spleen/metabolism
EDAT- 2007/10/20 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/20 09:00
PHST- 2007/10/20 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/20 09:00 [entrez]
AID - 179/9/6255 [pii]
AID - 10.4049/jimmunol.179.9.6255 [doi]
PST - ppublish
SO  - J Immunol. 2007 Nov 1;179(9):6255-62. doi: 10.4049/jimmunol.179.9.6255.