PMID- 17948029
OWN - NLM
STAT- MEDLINE
DCOM- 20080304
LR  - 20081121
IS  - 1350-9047 (Print)
IS  - 1350-9047 (Linking)
VI  - 15
IP  - 1
DP  - 2008 Jan
TI  - The 'kiss of death' by dendritic cells to cancer cells.
PG  - 58-69
AB  - Dendritic cells (DCs) are professional antigen-presenting cells (APCs) 
      specialized in the stimulation of naive T lymphocytes, which are key components 
      of antiviral and antitumor immunity. DCs are 'sentinels' of the immune system 
      endowed with the mission to (1) sense invading pathogens as well as any form of 
      tissue distress and (2) alert the effectors of the immune response. They 
      represent a very heterogeneous population including subsets characterized by 
      their anatomical locations and specific missions. Beyond their unique APC 
      features, DCs exhibit a large array of effector functions that play critical 
      roles in the induction and regulation of the cell-mediated as well as humoral 
      immune responses. In the course of the antitumor immune response, DCs are unique 
      in engulfing tumor cells killed by natural killer (NK) cells and cross-presenting 
      tumor-associated antigens to cytotoxic T lymphocytes (CTLs). However, while DCs 
      mediate antitumor immune responses by stimulating tumor-specific CTLs and NK 
      cells, direct tumoricidal mechanisms have been recently evoked. This review 
      addresses the other face of DCs to directly deliver apoptotic signals to stressed 
      cells, their role in tumor cell death, and its implication in the design of 
      DC-based cancer immunotherapies.
FAU - Chan, C W
AU  - Chan CW
AD  - Department of Cell Biology and Human Anatomy, University of California-Davis 
      School of Medicine, Sacramento, CA 95817, USA. camchan@ucdavis.edu
FAU - Housseau, F
AU  - Housseau F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20071019
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antigens, Neoplasm/*immunology
MH  - *Apoptosis
MH  - Cytotoxicity, Immunologic
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immunity, Innate
MH  - Immunologic Surveillance
MH  - Immunotherapy
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Neoplasms/*immunology/pathology/*physiopathology
MH  - Receptors, Cell Surface/immunology
MH  - Signal Transduction
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Toll-Like Receptors/immunology
RF  - 92
EDAT- 2007/10/20 09:00
MHDA- 2008/03/05 09:00
CRDT- 2007/10/20 09:00
PHST- 2007/10/20 09:00 [pubmed]
PHST- 2008/03/05 09:00 [medline]
PHST- 2007/10/20 09:00 [entrez]
AID - 4402235 [pii]
AID - 10.1038/sj.cdd.4402235 [doi]
PST - ppublish
SO  - Cell Death Differ. 2008 Jan;15(1):58-69. doi: 10.1038/sj.cdd.4402235. Epub 2007 
      Oct 19.