PMID- 1795015
OWN - NLM
STAT- MEDLINE
DCOM- 19920403
LR  - 20061115
IS  - 0730-2312 (Print)
IS  - 0730-2312 (Linking)
VI  - 47
IP  - 4
DP  - 1991 Dec
TI  - The nucleus: a black box being opened.
PG  - 311-6
AB  - Until recently our knowledge about the structural and functional organization of 
      the cell nucleus was very limited. Recent technical developments in the field of 
      ultrastructural analysis, combined with ongoing research on the properties of the 
      nuclear matrix, give new insight into how the nucleus is structured. Two types of 
      observations shape our ideas about nuclear organization. First, most nuclear 
      functions (replication, transcription, RNA processing, and RNA transport) are 
      highly localized within the nucleus, rather than diffusely distributed. Moreover, 
      they are associated with the nuclear matrix. Second, chromatin is organized in 
      discrete loops, bordered by nuclear matrix attachment sequences (MARs). Each loop 
      may contain one or several genes. The arrangement of chromatin in loops has 
      profound consequences for the regulation of gene expression.
FAU - van Driel, R
AU  - van Driel R
AD  - E.C. Slater Institute for Biochemical Research, University of Amsterdam, The 
      Netherlands.
FAU - Humbel, B
AU  - Humbel B
FAU - de Jong, L
AU  - de Jong L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Chromatin)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/*physiology
MH  - Chromatin/metabolism
MH  - Humans
MH  - Nuclear Matrix/metabolism/physiology
RF  - 64
EDAT- 1991/12/01 00:00
MHDA- 1991/12/01 00:01
CRDT- 1991/12/01 00:00
PHST- 1991/12/01 00:00 [pubmed]
PHST- 1991/12/01 00:01 [medline]
PHST- 1991/12/01 00:00 [entrez]
AID - 10.1002/jcb.240470405 [doi]
PST - ppublish
SO  - J Cell Biochem. 1991 Dec;47(4):311-6. doi: 10.1002/jcb.240470405.