PMID- 17950256
OWN - NLM
STAT- MEDLINE
DCOM- 20080716
LR  - 20191210
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 63
IP  - 11
DP  - 2008 Jun 1
TI  - CB1 cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute 
      responses and reinforcement.
PG  - 1030-8
AB  - BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) is a popular recreational 
      drug widely abused by young people. The endocannabinoid system is involved in the 
      addictive processes induced by different drugs of abuse. However, the role of 
      this system in the pharmacological effects of MDMA has not yet been clarified. 
      METHODS: Locomotion, body temperature, and anxiogenic-like responses were 
      evaluated after acute MDMA administration in CB(1) cannabinoid receptor 1 
      knockout mice. Additionally, MDMA rewarding properties were investigated in the 
      place conditioning and the intravenous self-administration paradigms. 
      Extracellular levels of dopamine (DA) in the nucleus accumbens were also analyzed 
      after a single administration of MDMA by in vivo microdialysis. RESULTS: Acute 
      MDMA administration increased locomotor activity, body temperature, and 
      anxiogenic-like responses in wild-type mice, but these responses were lower or 
      abolished in knockout animals. 3,4-Methylenedioxymethamphetamine produced similar 
      conditioned place preference and increased dopamine extracellular levels in the 
      nucleus accumbens in both genotypes. Nevertheless, CB(1) knockout mice failed to 
      self-administer MDMA at any of the doses used. CONCLUSIONS: These results 
      indicate that CB(1) cannabinoid receptors play an important role in the acute 
      prototypical effects of MDMA and are essential in the acquisition of an operant 
      behavior to self-administer this drug.
FAU - Tourino, Clara
AU  - Tourino C
AD  - Grup de Recerca de Neurobiologia del Comportament (GRNC), Departament de Ciencies 
      de Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
FAU - Ledent, Catherine
AU  - Ledent C
FAU - Maldonado, Rafael
AU  - Maldonado R
FAU - Valverde, Olga
AU  - Valverde O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071024
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Hallucinogens)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Anxiety/chemically induced
MH  - Behavior, Animal/drug effects
MH  - Body Temperature/drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Routes
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Microdialysis/methods
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Receptor, Cannabinoid, CB1/deficiency/*physiology
MH  - *Reinforcement, Psychology
MH  - Self Administration
EDAT- 2007/10/24 09:00
MHDA- 2008/07/17 09:00
CRDT- 2007/10/24 09:00
PHST- 2007/03/02 00:00 [received]
PHST- 2007/07/27 00:00 [revised]
PHST- 2007/09/04 00:00 [accepted]
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
AID - S0006-3223(07)00848-7 [pii]
AID - 10.1016/j.biopsych.2007.09.003 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2008 Jun 1;63(11):1030-8. doi: 10.1016/j.biopsych.2007.09.003. 
      Epub 2007 Oct 24.