PMID- 17950272
OWN - NLM
STAT- MEDLINE
DCOM- 20080403
LR  - 20151119
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 578
IP  - 2-3
DP  - 2008 Jan 14
TI  - Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat 
      hippocampus after treatment with selective and mixed monoaminergic 
      antidepressants.
PG  - 114-22
AB  - Strong evidence suggests that antidepressants work by induction of neuroplastic 
      changes mediated through regulation of brain-derived neurotrophic factor (BDNF). 
      This study was undertaken to investigate the time-course of the effect of three 
      antidepressants; fluoxetine, imipramine and venlafaxine, which differentially 
      affect monoamine reuptake, on BDNF mRNA expression in the hippocampus. The 
      consequences of increased BDNF in the hippocampus are still indefinite. Here, we 
      also determined the effects on the expression of two other genes (synaptophysin 
      and growth-associated protein-43 (GAP-43)) known to be involved in synapse 
      formation and axonal growth and likely regulated by BDNF. The effects were 
      determined in rats after sub-chronic (7 days) and chronic (14 and 21 days) 
      treatment using semi-quantitative in situ hybridisation. BDNF mRNA levels in the 
      dentate gyrus (DG) were increased after treatment with venlafaxine (7, 14 and 21 
      days) and imipramine (14 and 21 days), but not after treatment with fluoxetine, 
      indicating that stimulation of BDNF mRNA expression is dependent on the 
      pharmacological profile and on the time-course of drug treatment. A transient 
      increase in synaptophysin mRNA was observed after treatment with venlafaxine and 
      fluoxetine whereas imipramine had no effect. In the CA3 region a reduction of 
      GAP-43 mRNA was observed after treatment with imipramine (21 days) and fluoxetine 
      (7 and 14 days). These results suggest that venlafaxine and imipramine, but not 
      fluoxetine, induce neuroplastic effects in the hippocampus through stimulation of 
      BDNF mRNA expression, and that the effect on BDNF is not directly translated into 
      regulation of synaptophysin and GAP-43 mRNA.
FAU - Larsen, Marianne H
AU  - Larsen MH
AD  - Neurosearch A/S, Ballerup, Denmark. haldlarsen@hotmail.com
FAU - Hay-Schmidt, Anders
AU  - Hay-Schmidt A
FAU - Ronn, Lars C B
AU  - Ronn LC
FAU - Mikkelsen, Jens D
AU  - Mikkelsen JD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070926
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclohexanols)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Neurotransmitter Uptake Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Synaptophysin)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 7D7RX5A8MO (Venlafaxine Hydrochloride)
RN  - OGG85SX4E4 (Imipramine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cyclohexanols/*pharmacology
MH  - Dentate Gyrus/drug effects/metabolism
MH  - Fluoxetine/*pharmacology
MH  - GAP-43 Protein/metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - Imipramine/*pharmacology
MH  - Male
MH  - Neuronal Plasticity/drug effects
MH  - Neurotransmitter Uptake Inhibitors/*pharmacology
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptophysin/metabolism
MH  - Time Factors
MH  - Transcription, Genetic/drug effects
MH  - Venlafaxine Hydrochloride
EDAT- 2007/10/24 09:00
MHDA- 2008/04/04 09:00
CRDT- 2007/10/24 09:00
PHST- 2007/05/15 00:00 [received]
PHST- 2007/08/13 00:00 [revised]
PHST- 2007/08/28 00:00 [accepted]
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2008/04/04 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
AID - S0014-2999(07)01035-7 [pii]
AID - 10.1016/j.ejphar.2007.08.050 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2008 Jan 14;578(2-3):114-22. doi: 10.1016/j.ejphar.2007.08.050. 
      Epub 2007 Sep 26.