PMID- 17950666
OWN - NLM
STAT- MEDLINE
DCOM- 20080229
LR  - 20211020
IS  - 1471-4906 (Print)
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 28
IP  - 11
DP  - 2007 Nov
TI  - The interaction of HIV with dendritic cells: outcomes and pathways.
PG  - 503-10
AB  - Dendritic cells (DCs), including Langerhans Cells (LCs), are probably among the 
      earliest targets of HIV infection. Their localization in mucosal epithelia and in 
      the T cell areas of lymphoid organs, as well as their crucial role in capturing 
      antigens and initiating T cell responses, highlight their potential importance. 
      Studies with cells in culture have addressed different outcomes of the HIV--DC 
      interaction, which include: direct productive infection of DC; carriage of virus 
      by DC to CD4+ T cells; transfer of virus between DC and T cells at an infectious 
      synapse; and immune evasion strategies of infected DC. Here we review the 
      literature covering these areas, including current knowledge of underlying 
      mechanisms or pathways.
FAU - Piguet, Vincent
AU  - Piguet V
AD  - Department of Dermatology and Venereology, University Hospital and Medical School 
      of Geneva, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland. 
      vincent.piguet@medecine.unige.ch
FAU - Steinman, Ralph M
AU  - Steinman RM
LA  - eng
GR  - N01AI40045/AI/NIAID NIH HHS/United States
GR  - AI40045/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071022
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Receptors, HIV)
SB  - IM
MH  - Antigen Presentation
MH  - CD4-Positive T-Lymphocytes/immunology/*virology
MH  - Dendritic Cells/*immunology/*virology
MH  - HIV/immunology/*physiology
MH  - HIV Infections/*immunology/virology
MH  - Humans
MH  - Intercellular Junctions/physiology
MH  - Receptors, HIV/physiology
MH  - Virus Internalization
PMC - PMC7106400
EDAT- 2007/10/24 09:00
MHDA- 2008/03/01 09:00
PMCR- 2007/10/23
CRDT- 2007/10/24 09:00
PHST- 2007/07/27 00:00 [received]
PHST- 2007/07/27 00:00 [revised]
PHST- 2007/07/27 00:00 [accepted]
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2008/03/01 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
PHST- 2007/10/23 00:00 [pmc-release]
AID - S1471-4906(07)00225-6 [pii]
AID - 10.1016/j.it.2007.07.010 [doi]
PST - ppublish
SO  - Trends Immunol. 2007 Nov;28(11):503-10. doi: 10.1016/j.it.2007.07.010. Epub 2007 
      Oct 22.