PMID- 17950920
OWN - NLM
STAT- MEDLINE
DCOM- 20071211
LR  - 20071022
IS  - 1083-8791 (Print)
IS  - 1083-8791 (Linking)
VI  - 13
IP  - 11
DP  - 2007 Nov
TI  - Comparable long-term survival after bone marrow versus peripheral blood 
      progenitor cell transplantation from matched unrelated donors in children with 
      hematologic malignancies.
PG  - 1338-45
AB  - Despite the increasing use of peripheral blood progenitor cells (PBPC) instead of 
      bone marrow (BM) for allogeneic hematopoietic stem cell transplantation (allo 
      HSCT) from human leukocyte antigen (HLA)-matched unrelated donors in children, 
      the relative benefits and risks of both stem cell sources in the pediatric 
      setting remain largely unknown. Recently, the only larger study comparing the 
      value of the 2 stem cell sources in a young patient group was confined to 
      transplantation from HLA-identical sibling donors in older children and 
      adolescents with acute leukemia. Based on the paucity of data in pediatric 
      HLA-matched unrelated donor transplantation, we analyzed the outcome of 23 BM and 
      38 PBPC transplantations performed at our center. Neutrophil and platelet 
      engraftment were achieved significantly faster in PBPC compared to BM recipients 
      (18 versus 22 days and 26 versus 33 days; P < .001 and P = .03) whereas the risk 
      for grade II-IV acute graft-versus-host disease (aGVHD) (62% versus 55%; P = .53) 
      and chronic GVHD (cGVHD 65% versus 59%; P = .54) was comparable. As overall 
      survival (OS; PBPC versus BM: 47.5% +/- 8.6% versus 51.8% +/- 10.5%; P = .88) and 
      relapse-free survival (43.3% +/- 8.3% versus 51.8% +/- 10.5%; P = .60) are 
      without detectable difference, PBPC and BM appear both as a valid stem cell 
      source for HLA-matched unrelated donor transplantation in children with 
      hematologic malignancies.
FAU - Meisel, Roland
AU  - Meisel R
AD  - Clinic for Pediatric Oncology, Hematology and Clinical Immunology, University 
      Clinic of Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany. 
      meisel@med.uni-duesseldorf.de
FAU - Laws, Hans-Jurgen
AU  - Laws HJ
FAU - Balzer, Stefan
AU  - Balzer S
FAU - Bernbeck, Benedikt
AU  - Bernbeck B
FAU - Kramm, Christof
AU  - Kramm C
FAU - Schonberger, Stefan
AU  - Schonberger S
FAU - Sinha, Kumar
AU  - Sinha K
FAU - Troger, Anja
AU  - Troger A
FAU - Schmitz, Monika
AU  - Schmitz M
FAU - Fischer, Johannes
AU  - Fischer J
FAU - Gobel, Ulrich
AU  - Gobel U
FAU - Enczmann, Jurgen
AU  - Enczmann J
FAU - Dilloo, Dagmar
AU  - Dilloo D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070921
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Adolescent
MH  - Bone Marrow Transplantation/*adverse effects/methods/mortality
MH  - Child
MH  - Child, Preschool
MH  - Disease-Free Survival
MH  - Female
MH  - Germany/epidemiology
MH  - Graft Survival
MH  - Graft vs Host Disease
MH  - Hematologic Neoplasms/*therapy
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*methods/mortality
MH  - Humans
MH  - Infant
MH  - Male
MH  - Peripheral Blood Stem Cell Transplantation/*adverse effects/methods/mortality
MH  - Retrospective Studies
MH  - Survivors
MH  - Transplantation, Homologous/adverse effects/mortality
EDAT- 2007/10/24 09:00
MHDA- 2007/12/12 09:00
CRDT- 2007/10/24 09:00
PHST- 2007/05/29 00:00 [received]
PHST- 2007/07/16 00:00 [accepted]
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2007/12/12 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
AID - S1083-8791(07)00353-9 [pii]
AID - 10.1016/j.bbmt.2007.07.009 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2007 Nov;13(11):1338-45. doi: 
      10.1016/j.bbmt.2007.07.009. Epub 2007 Sep 21.