PMID- 17951478
OWN - NLM
STAT- MEDLINE
DCOM- 20080312
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 137
IP  - 11
DP  - 2007 Nov
TI  - Dietary fat subgroups, zinc, and vegetable components are related to urine 
      F2a-isoprostane concentration, a measure of oxidative stress, in midlife women.
PG  - 2412-9
AB  - Smoking, diet, and physical activity may impact chronic diseases in part by 
      promoting or attenuating oxidative stress. We evaluated associations between 
      lifestyle factors and urine F(2a)-isoprostanes, a marker of oxidative stress in 
      1610 participants of the Study of Women's Health Across the Nation (SWAN). 
      Dietary intake and physical activity were assessed at baseline and the 5th year 
      05 (Y05). These data were related to Y05 urinary F(2a)-isoprostane concentration 
      with regression analyses. Median urine F(2a)-isoprostane concentration was 433 
      ng/L overall, 917 ng/L in smokers [inter-quartile range (IQR): 467, 1832 ng/L], 
      and 403 ng/L in nonsmokers (IQR: 228, 709 ng/L; P < 0.0001 for difference). 
      Higher trans fat intake was associated with higher urine F(2a)-isoprostane 
      concentration; partial Spearman correlations (rho(x|y)) between Y05 urine 
      F(2a)-isoprostane concentration and trans fatty acids was 0.19 (P = 0.03) in 
      smokers and 0.13 (P < 0.0001) in nonsmokers. Increased log trans fat intake from 
      baseline to Y05 was associated with higher concentration of log urine 
      F(2a)-isoprostanes in nonsmokers (beta = 0.131, SE = 0.04, P = 0.0003). In 
      nonsmokers, the partial correlation (rho(x|y)) between lutein and urine 
      F(2a)-isoprostane concentration was -0.13 (P < 0.0001). Increased intake of log 
      lutein from baseline to Y05 was also associated with lower log urine 
      F(2a)-isoprostane concentration (beta = -0.096, SE = 0.03, P = 0.0005) in 
      nonsmokers. Increased zinc intake from baseline to Y05 was associated with lower 
      log urine F(2a)-isoprostane concentration in smokers and nonsmokers (beta = 
      -0.346, SE = 0.14, P = 0.01), and -0.117, 0.04 (P = 0.001), respectively]. In 
      conclusion, diet (fat subtypes, zinc, and vegetable components) and smoking were 
      associated with urine F(2a)-isoprostanes, a marker of oxidative stress.
FAU - Tomey, Kristin M
AU  - Tomey KM
AD  - Department of Epidemiology, School of Public Health, University of Michigan, Ann 
      Arbor, MI 48104, USA.
FAU - Sowers, MaryFran R
AU  - Sowers MR
FAU - Li, Xizhao
AU  - Li X
FAU - McConnell, Daniel S
AU  - McConnell DS
FAU - Crawford, Sybil
AU  - Crawford S
FAU - Gold, Ellen B
AU  - Gold EB
FAU - Lasley, Bill
AU  - Lasley B
FAU - Randolph, John F Jr
AU  - Randolph JF Jr
LA  - eng
GR  - AG012554/AG/NIA NIH HHS/United States
GR  - AG012531/AG/NIA NIH HHS/United States
GR  - U01 AG012495/AG/NIA NIH HHS/United States
GR  - U01 AG012505/AG/NIA NIH HHS/United States
GR  - AG012535/AG/NIA NIH HHS/United States
GR  - AG012546/AG/NIA NIH HHS/United States
GR  - AG017719/AG/NIA NIH HHS/United States
GR  - U01 NR004061-14/NR/NINR NIH HHS/United States
GR  - AG012553/AG/NIA NIH HHS/United States
GR  - NR004061/NR/NINR NIH HHS/United States
GR  - U01 AG012554/AG/NIA NIH HHS/United States
GR  - U01 AG017719-10/AG/NIA NIH HHS/United States
GR  - AG012539/AG/NIA NIH HHS/United States
GR  - U01 AG012535/AG/NIA NIH HHS/United States
GR  - U01 AG012553/AG/NIA NIH HHS/United States
GR  - U01 NR004061/NR/NINR NIH HHS/United States
GR  - U01 AG012539/AG/NIA NIH HHS/United States
GR  - AG012495/AG/NIA NIH HHS/United States
GR  - U01 AG012546/AG/NIA NIH HHS/United States
GR  - U01 AG012531/AG/NIA NIH HHS/United States
GR  - U01 AG017719/AG/NIA NIH HHS/United States
GR  - AG012505/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Biomarkers)
RN  - 0 (Dietary Fats)
RN  - 0 (Isoprostanes)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adult
MH  - Biomarkers/*urine
MH  - Brassica
MH  - Dietary Fats/*classification/*pharmacology
MH  - Female
MH  - Humans
MH  - Isoprostanes/*urine
MH  - Life Style
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Regression Analysis
MH  - *Vegetables
MH  - Zinc/*pharmacology
PMC - PMC2730459
MID - NIHMS120848
EDAT- 2007/10/24 09:00
MHDA- 2008/03/13 09:00
PMCR- 2009/08/22
CRDT- 2007/10/24 09:00
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2008/03/13 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
PHST- 2009/08/22 00:00 [pmc-release]
AID - S0022-3166(22)09421-4 [pii]
AID - 10.1093/jn/137.11.2412 [doi]
PST - ppublish
SO  - J Nutr. 2007 Nov;137(11):2412-9. doi: 10.1093/jn/137.11.2412.