PMID- 17953907
OWN - NLM
STAT- MEDLINE
DCOM- 20080201
LR  - 20191210
IS  - 0025-7753 (Print)
IS  - 0025-7753 (Linking)
VI  - 129
IP  - 12
DP  - 2007 Oct 6
TI  - [Left atrium diameter: a simple echocardiographic parameter with high prognostic 
      value in heart failure].
PG  - 441-5
AB  - BACKGROUND AND OBJECTIVE: Left atrium diameter (LAD) is a very simple and easy 
      parameter to obtain by echocardiography. It is influenced by systolic and 
      diastolic ventricular dysfunction and by the coexistence of mitral regurgitation. 
      We evaluated LAD as a predictor of prognosis (2 year mortality) in a heart 
      failure (HF) population admitted to an outpatient HF unit. We compared LAD 
      (mm/m2) with other echocardiographic parameters (left ventricular ejection 
      fraction, left ventricular end-diastolic and end-systolic diameters [mm/m2], 
      mitral regurgitation, degree of diastolic dysfunction and pulmonary artery 
      pressure). PATIENTS AND METHOD: We studied 368 patients (73% men; mean age 
      [standard deviation]: 65.2 [11] years; 60% of ischemic etiology). The mean left 
      ventricular ejection fraction by echocardiography was 32.3% (13.1%). The majority 
      of patients were in NYHA (New York Heart Association) class II (48%) or III 
      (43%). RESULTS: Two years mortality was 20.6%. In the univariate analysis LAD (p 
      < 0.001), left ventricular end-diastolic diameter (p < 0.001), left ventricular 
      end-systolic diameter (p = 0.003), the degree of mitral regurgitation (p = 0.002) 
      and the pattern of diastolic dysfunction (p = 0.004) showed a significant 
      relationship with 2 years mortality, but not left ventricular ejection fraction 
      and pulmonary pressure. In the echocardiographic multivariate analysis, only LAD 
      remained significantly associated with mortality. In the multivariate analysis 
      including important clinical parameters such as age, sex, etiology, time lapsed 
      since symptoms onset, NYHA functional class, and the presence of diabetes, 
      hypertension and atrial fibrillation, LAD remained as independent predictor of 2 
      years mortality. Patients with LAD less than 25 mm/m2 have a 10.9% mortality, 
      whereas those with LAD equal or greater than 25 mm/m2 have a 30.1% mortality (p < 
      0.001). CONCLUSIONS: LAD was a good predictor of 2 years mortality, better than 
      other echocardiographic parameters in patients of our outpatient HF unit and was 
      independent of strong clinical parameters.
FAU - Zamora, Elisabet
AU  - Zamora E
AD  - Unitat d'Insuficiencia Cardiaca, Servicio de Cardiologia, Hospital Universitari 
      Germans Trias i Pujol, Badalona, Barcelona, Espana.
FAU - Lupon, Josep
AU  - Lupon J
FAU - Lopez-Ayerbe, Jorge
AU  - Lopez-Ayerbe J
FAU - Urrutia, Agustin
AU  - Urrutia A
FAU - Gonzalez, Beatriz
AU  - Gonzalez B
FAU - Ferrer, Elena
AU  - Ferrer E
FAU - Vallejo, Nuria
AU  - Vallejo N
FAU - Valle, Vicente
AU  - Valle V
LA  - spa
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
TT  - Diametro de la auricula izquierda: un parametro ecocardiografico sencillo con 
      importante significado pronostico en la insuficiencia cardiaca.
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Atrial Fibrillation/complications
MH  - Atrial Function, Left
MH  - Data Interpretation, Statistical
MH  - Diabetes Complications
MH  - Diastole
MH  - *Echocardiography, Doppler
MH  - Female
MH  - Heart Atria/*diagnostic imaging
MH  - Heart Failure/complications/*diagnosis/mortality/physiopathology
MH  - Humans
MH  - Hypertension/complications
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/physiopathology
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Sex Factors
MH  - Stroke Volume
MH  - Ventricular Function, Left
EDAT- 2007/10/24 09:00
MHDA- 2008/02/02 09:00
CRDT- 2007/10/24 09:00
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2008/02/02 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
AID - S0025-7753(07)72881-6 [pii]
AID - 10.1157/13111001 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2007 Oct 6;129(12):441-5. doi: 10.1157/13111001.