PMID- 17954176
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20071023
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 39
IP  - 8
DP  - 2007 Oct
TI  - Human platelet antigens: HPA-1, -2, -3, -4, and -5 polymorphisms in kidney 
      transplantation.
PG  - 2568-70
AB  - To investigate the association between kidney transplant rejection and 
      polymorphisms of HPA-1, -2, -3, -4, and -5, the genomic DNA of 70 renal 
      transplant recipients and 100 healthy blood donors was analyzed by polymerase 
      chain reaction (PCR)-SSP. The patients were classified into two groups. Group 1 
      included 33 HLA-identical recipients and group 2, 37 one haplo-identical 
      recipients. Thirty-one recipients experienced an acute rejection episode (ARE): 
      10 in group 1 and 21 in group 2. Ten group 2 patients developed chronic allograft 
      dysfunction (CAD). Before transplantation, five patients in group 1 were 
      lymphocytocytotoxic antibodies (LCT) positive, among them three developed an ARE. 
      In group 2, seven recipients were LCT positive and four had an ARE. After 
      transplantation, 29 patients were LCT positive: 11 in group 1 and 18 in group 2, 
      among them: 6/11 and 11/18 had an ARE. The allelic frequencies of HPA-1, -2, and 
      -5 among patients and controls did not reveal significant differences, whereas 
      the HPA-3a and HPA-4b alleles were significantly more frequent among patients 
      than controls: 91.4% and 27.8% versus 76.5% and 11.5% respectively (P < .05 and P 
      < .001). The frequency of the HPA-3b allele was increased in patients with an ARE 
      (11.3%) and those who developed CAD (20%) compared with those not affected by 
      these complications (6.6% and 6.4%, respectively), but the difference was not 
      significant. The genotype distribution of HPA-1, -3, and -4 genes of GPIIb/IIIa 
      revealed that the most frequent genotype was HPA-1a1a/3a3a/4a4a (19%) among 
      controls and HPA-1a1a/3a3a/4a4b (31.4%) among patients. This genotype was 
      associated with an ARE in 25.8%, namely 50% of group 1 recipients and 14.28% of 
      group 2. The HPA-4b polymorphism of GPIIb/IIIa receptor seem to be an independent 
      risk factor for acute allograft rejection in kidney transplantation.
FAU - Gorgi, Y
AU  - Gorgi Y
AD  - Laboratory of Immunology, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006 
      Tunis, Tunisia. yousr.gorgi@rns.tn
FAU - Sfar, I
AU  - Sfar I
FAU - Ben Abdallah, T
AU  - Ben Abdallah T
FAU - Aouadi, H
AU  - Aouadi H
FAU - Abderrahim, E
AU  - Abderrahim E
FAU - Bardi, R
AU  - Bardi R
FAU - Jendoubi-Ayed, S
AU  - Jendoubi-Ayed S
FAU - Ayed, K
AU  - Ayed K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Antigens, Human Platelet)
SB  - IM
MH  - Antigens, Human Platelet/*genetics/immunology
MH  - Blood Platelets/*immunology
MH  - Genotype
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - *Polymorphism, Genetic
MH  - Reference Values
EDAT- 2007/10/24 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/24 09:00
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
AID - S0041-1345(07)00951-7 [pii]
AID - 10.1016/j.transproceed.2007.08.032 [doi]
PST - ppublish
SO  - Transplant Proc. 2007 Oct;39(8):2568-70. doi: 10.1016/j.transproceed.2007.08.032.