PMID- 17954269
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20211020
IS  - 0165-4608 (Print)
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 178
IP  - 2
DP  - 2007 Oct 15
TI  - Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group 
      of ovarian stromal tumors.
PG  - 135-40
AB  - Traditional cytogenetic studies of ovarian stromal tumors are few, although 
      trisomy 12 has been frequently documented with fluorescence in situ hybridization 
      (FISH). In the current study, karyotypic analysis of four ovarian stromal tumors 
      and a review of the literature suggest that numerical abnormalities of 
      chromosomes 4 and 9 might also be important, possibly as secondary changes. To 
      determine the frequency of 4, 9, and 12 aneuploidy in a larger group of ovarian 
      tumors, FISH studies were performed on eight fibromas, three thecomas, one 
      fibrothecoma, and five cellular fibromas. Trisomy 12 was identified in all five 
      cellular fibromas as well as in two fibromas and the fibrothecoma. Gain of 
      chromosome 9 was confined to the cellular fibromas. Loss of chromosomes 4 and/or 
      9 was prominent in the fibromas. These findings confirm the presence of trisomy 
      12 as a nonrandom chromosomal abnormality in ovarian stromal tumors. Moreover, 
      these conventional and molecular cytogenetic data indicate that gain of 
      chromosome 9 in addition to gain of chromosome 12 is prominent in cellular 
      fibroma. In contrast, loss of chromosomes 4 and/or 9 are recurrent in fibroma. In 
      summary, imbalances of chromosomes 4 and 9 appear to represent important 
      secondary abnormalities in the thecoma-fibroma ovarian tumor group.
FAU - Streblow, Renae C
AU  - Streblow RC
AD  - Departments of Pathology and Microbiology, University of Nebraska Medical Center, 
      983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.
FAU - Dafferner, Alicia J
AU  - Dafferner AJ
FAU - Nelson, Marilu
AU  - Nelson M
FAU - Fletcher, Mavis
AU  - Fletcher M
FAU - West, William W
AU  - West WW
FAU - Stevens, Rachel K
AU  - Stevens RK
FAU - Gatalica, Zoran
AU  - Gatalica Z
FAU - Novak, Deborah
AU  - Novak D
FAU - Bridge, Julia A
AU  - Bridge JA
LA  - eng
GR  - P30 CA036727/CA/NCI NIH HHS/United States
GR  - P30 CA036727-23/CA/NCI NIH HHS/United States
GR  - P30 CA3672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Allelic Imbalance
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 4
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Fibroma/*genetics/pathology
MH  - Humans
MH  - Karyotyping
MH  - Middle Aged
MH  - Ovarian Neoplasms/*genetics/pathology
MH  - Recurrence
MH  - Thecoma/*genetics/pathology
PMC - PMC4275003
MID - NIHMS33742
EDAT- 2007/10/24 09:00
MHDA- 2007/12/07 09:00
PMCR- 2014/12/23
CRDT- 2007/10/24 09:00
PHST- 2007/04/10 00:00 [received]
PHST- 2007/07/05 00:00 [revised]
PHST- 2007/07/11 00:00 [accepted]
PHST- 2007/10/24 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/24 09:00 [entrez]
PHST- 2014/12/23 00:00 [pmc-release]
AID - S0165-4608(07)00436-0 [pii]
AID - 10.1016/j.cancergencyto.2007.07.009 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Oct 15;178(2):135-40. doi: 
      10.1016/j.cancergencyto.2007.07.009.