PMID- 17956497
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20131121
IS  - 1360-2276 (Print)
IS  - 1360-2276 (Linking)
VI  - 12
IP  - 10
DP  - 2007 Oct
TI  - Immune responses after single-dose sulphadoxine-pyrimethamine indicate 
      underestimation of protective efficacy of intermittent preventive treatment in 
      infants.
PG  - 1157-63
AB  - OBJECTIVE: To assess how intermittent preventive treatment in infants (IPTi) with 
      sulphadoxine-pyrimethamine (SP) affects Immunoglobulin (IgG) immune responses 
      against Plasmodium falciparum in infants from rural Ghana. METHODS: Randomized, 
      placebo-controlled and double-blinded clinical trial with participants randomized 
      in blocks of 10 to receive either 250 mg sulphadoxine/2.5 mg pyrimethamine or 
      placebo at the age of 3 (IPTi-1), 9 (IPTi-2) and 15 (IPTi-3) months and 
      followed-up for 21 months. (i) Anti-P. falciparum IgG levels were measured in 180 
      children at the age of 9 months. (ii) Longitudinal study of the relationship 
      between IgG levels and P. falciparum infections and/or clinical malaria in 17 
      naive children until they reached the age of 2 years. RESULTS: IgG antibody 
      levels against crude P. falciparum lysate were dependent on the frequency of 
      preceding infections and significantly lower in children treated with SP. 
      CONCLUSION: Placebo-treated children had an indifferentially higher incidence of 
      P. falciparum infections than clinically observed, which implicates an 
      underestimation of the protective efficacy of IPTi. IgG profiles in 17 children 
      followed up until the age of 2 years provided no evidence for impaired immune 
      responses after a single dose of SP within the framework of IPTi.
FAU - Schreiber, Nadine
AU  - Schreiber N
AD  - Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical 
      Medicine, Hamburg, Germany.
FAU - Kobbe, Robin
AU  - Kobbe R
FAU - Adjei, Samuel
AU  - Adjei S
FAU - Adjei, Ohene
AU  - Adjei O
FAU - Klinkert, Mo-Quen
AU  - Klinkert MQ
FAU - May, Jurgen
AU  - May J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
RN  - 0 (Antimalarials)
RN  - 0 (Drug Combinations)
RN  - 0 (Immunoglobulin G)
RN  - 37338-39-9 (fanasil, pyrimethamine drug combination)
RN  - 88463U4SM5 (Sulfadoxine)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
MH  - Animals
MH  - Antimalarials/*therapeutic use
MH  - Child
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Ghana/epidemiology
MH  - Humans
MH  - Immunoglobulin G/*immunology
MH  - Incidence
MH  - Infant
MH  - Malaria, Falciparum/epidemiology/*immunology/prevention & control
MH  - *Plasmodium falciparum
MH  - Pyrimethamine/*therapeutic use
MH  - Sulfadoxine/*therapeutic use
EDAT- 2007/10/25 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/10/25 09:00
PHST- 2007/10/25 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/10/25 09:00 [entrez]
AID - TMI1902 [pii]
AID - 10.1111/j.1365-3156.2007.01902.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2007 Oct;12(10):1157-63. doi: 
      10.1111/j.1365-3156.2007.01902.x.