PMID- 17958396
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20211020
IS  - 0163-3864 (Print)
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 70
IP  - 11
DP  - 2007 Nov
TI  - Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.
PG  - 1824-6
AB  - The lipid extract of an Indonesian Lendenfeldia sp. sponge inhibited 
      hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D breast 
      tumor cells. Chromatographic separation yielded the new substituted naphthalene 
      dimer 1, the new furanolipid 2, and three known homoscalarane sesterterpenes, 
      3-5. Compounds 1 and 3-5 inhibited hypoxia-induced HIF-1 activation (IC50 values: 
      0.64-6.9 microM), but also reduced the viability of T47D and MDA-MB-231 breast 
      tumor cells. Compound 4 was the most potent and showed a unique tumor cell line 
      selectivity in the NCI 60-cell line panel. The general cytotoxicity of these 
      compounds precluded their further consideration as HIF-1 inhibitors.
FAU - Dai, Jingqiu
AU  - Dai J
AD  - Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, 
      School of Pharmacy, University of Mississippi, Mississippi 38677-1848, USA.
FAU - Liu, Yang
AU  - Liu Y
FAU - Zhou, Yu-Dong
AU  - Zhou YD
FAU - Nagle, Dale G
AU  - Nagle DG
LA  - eng
GR  - CA 98787/CA/NCI NIH HHS/United States
GR  - R01 CA098787-01A2/CA/NCI NIH HHS/United States
GR  - C06 RR014503/RR/NCRR NIH HHS/United States
GR  - C06 RR-14503-01/RR/NCRR NIH HHS/United States
GR  - R01 CA098787/CA/NCI NIH HHS/United States
GR  - R56 CA098787/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20071025
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Sesterterpenes)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*isolation & purification/*pharmacology
MH  - Drug Screening Assays, Antitumor
MH  - Hypoxia-Inducible Factor 1/*antagonists & inhibitors
MH  - Indonesia
MH  - Inhibitory Concentration 50
MH  - Luciferases/metabolism
MH  - Porifera/*chemistry
MH  - Sesterterpenes/chemistry/*isolation & purification/*pharmacology
PMC - PMC2782894
MID - NIHMS107360
EDAT- 2007/10/26 09:00
MHDA- 2008/01/08 09:00
PMCR- 2009/11/25
CRDT- 2007/10/26 09:00
PHST- 2007/10/26 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/10/26 09:00 [entrez]
PHST- 2009/11/25 00:00 [pmc-release]
AID - 10.1021/np070337f [doi]
PST - ppublish
SO  - J Nat Prod. 2007 Nov;70(11):1824-6. doi: 10.1021/np070337f. Epub 2007 Oct 25.