PMID- 17958728
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20161020
IS  - 1120-8694 (Print)
IS  - 1120-8694 (Linking)
VI  - 20
IP  - 6
DP  - 2007
TI  - Early experience with radiofrequency energy ablation therapy for Barrett's 
      esophagus with and without dysplasia.
PG  - 516-22
AB  - Radiofrequency (RF) ablation using the HALO(360) system combined with proton pump 
      inhibitor (PPI) therapy is a new treatment for Barrett's esophagus (BE). We 
      assessed the safety and effectiveness of this combination therapy at a 
      community-based, BE referral center. After symptom evaluation, endoscopy and 
      histologic assessment, esophageal motility, pH monitoring on PPI, computed 
      tomography, endoscopic ultrasonography and mucosal resection for nodules, we 
      performed HALO(360) ablation followed by twice daily PPI and 3-monthly 
      surveillance for up to 12 months. If metaplasia or dysplasia were present at 
      follow-up, the patients received a second ablation. Thirteen patients (12 male) 
      were treated, three with high-grade dysplasia, four with low-grade and six with 
      non-dysplastic intestinal metaplasia. The mean baseline BE length was 6 cm (range 
      2-12); nine patients had an hiatal hernia and two had a prior fundoplication. 
      Esophageal pH < 4.0 for < 4% of time was achieved only in 5/13 patients. A mean 
      of 1.4 ablation sessions were performed, without serious adverse events or 
      strictures. Complete eradication of BE was achieved in 6/13 (46%) patients. The 
      mean endoscopic surface regression was 84% (from a mean length of 6 +/- 1 cm to 
      1.2 +/- 0.5 cm, P < 0.001). Complete elimination of dysplasia was achieved in 5/7 
      (71%) patients. Ablation efficacy was better in those patients who had maximal pH 
      control (P < 0.05). HALO(360) ablation of BE with or without dysplasia is safe, 
      well-tolerated and effective in the community setting. Follow-up ablation further 
      reverses residual BE or dysplasia.
FAU - Roorda, A K
AU  - Roorda AK
AD  - Department of Internal Medicine, St Mary's Medical Center, San Francisco, 
      California, USA.
FAU - Marcus, S N
AU  - Marcus SN
FAU - Triadafilopoulos, G
AU  - Triadafilopoulos G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
SB  - IM
MH  - Adult
MH  - Aged
MH  - Barrett Esophagus/pathology/physiopathology/*radiotherapy
MH  - Biopsy
MH  - Endoscopy, Gastrointestinal
MH  - Female
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Middle Aged
MH  - *Radio Waves
EDAT- 2007/10/26 09:00
MHDA- 2008/02/28 09:00
CRDT- 2007/10/26 09:00
PHST- 2007/10/26 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2007/10/26 09:00 [entrez]
AID - DES728 [pii]
AID - 10.1111/j.1442-2050.2007.00728.x [doi]
PST - ppublish
SO  - Dis Esophagus. 2007;20(6):516-22. doi: 10.1111/j.1442-2050.2007.00728.x.