PMID- 17959306
OWN - NLM
STAT- MEDLINE
DCOM- 20080321
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 429
IP  - 1
DP  - 2007 Dec 11
TI  - The BDNF Val66Met polymorphism predicts rumination and depression differently in 
      young adolescent girls and their mothers.
PG  - 12-6
AB  - A single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor 
      (BDNF) gene Val66Met has been associated with depression. However, the 
      relationship between this SNP and depression has been mixed, especially when 
      comparing studies of child and adult depression. We examined whether Val66Met 
      would predict depression differentially in mothers versus their daughters. We 
      also examined whether rumination, the tendency to brood and repetitively think 
      about negative information, might serve as a mediator in the path between 
      genotype and depressive symptoms. Participants included 200 individuals (100 
      mother-daughter pairs) from a high-risk population. The BDNF Val66Met 
      polymorphism was examined in DNA samples from the mothers and daughters, and 
      measures of depressive symptoms and rumination were also obtained. Among the 
      young adolescent girls (ages 10-14), the Val/Val genotype was associated with 
      more depressive symptoms and higher rumination scores compared to the Val/Met 
      genotype. Furthermore, rumination mediated the relationship between genotype and 
      depressive symptoms. However, in the mothers with adult-onset depression the 
      Val/Met genotype was associated with more depressive symptoms, and rumination 
      again mediated the relationship between genotype and depression. Rumination may 
      be an endophenotype in the pathway from the BDNF Val66Met polymorphism to 
      depression. Future work should further explore this mechanism and pursue 
      explanations for its effects at different times in development.
FAU - Hilt, Lori M
AU  - Hilt LM
AD  - Department of Psychology, Yale University, New Haven, CT 06520-8250, United 
      States. lori.hilt@yale.edu
FAU - Sander, Lisa C
AU  - Sander LC
FAU - Nolen-Hoeksema, Susan
AU  - Nolen-Hoeksema S
FAU - Simen, Arthur A
AU  - Simen AA
LA  - eng
GR  - 1KL2RR024138/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071002
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Mutational Analysis/methods
MH  - Depression/*genetics
MH  - Family Health
MH  - Feeding and Eating Disorders of Childhood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - *Mother-Child Relations
MH  - *Polymorphism, Genetic
MH  - Valine/*genetics
EDAT- 2007/10/26 09:00
MHDA- 2008/03/22 09:00
CRDT- 2007/10/26 09:00
PHST- 2007/06/27 00:00 [received]
PHST- 2007/08/07 00:00 [revised]
PHST- 2007/09/24 00:00 [accepted]
PHST- 2007/10/26 09:00 [pubmed]
PHST- 2008/03/22 09:00 [medline]
PHST- 2007/10/26 09:00 [entrez]
AID - S0304-3940(07)01047-6 [pii]
AID - 10.1016/j.neulet.2007.09.053 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Dec 11;429(1):12-6. doi: 10.1016/j.neulet.2007.09.053. Epub 
      2007 Oct 2.