PMID- 17960555
OWN - NLM
STAT- MEDLINE
DCOM- 20080828
LR  - 20181201
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 103
IP  - 6
DP  - 2008 Apr 15
TI  - MMTV-EGF receptor transgene promotes preneoplastic conversion of multiple steroid 
      hormone-responsive tissues.
PG  - 2010-8
AB  - Correlative analyses of tumors and patient-derived cell lines of the human 
      reproductive system suggest that overexpression of EGF contributes to the 
      oncogenic phenotype. However, it is unclear at what stage in disease 
      overexpression of the EGFR is most critical. To assess its role as an initiator 
      of reproductive tissue tumor development, transgenic mice were derived with mouse 
      mammary tumor virus (MMTV)-regulated overexpression of the human EGFR. Although 
      elevated expression of the EGFR in hormonally responsive tissues was observed, 
      only one EGFR transgenic mouse developed a visible tumor over a 2-year period. 
      However, of 12 females monitored over the same time, hyperplasia, hypertrophy, or 
      slight dysplasia was found in mammary glands of 55% of the animals examined, in 
      the uterus or uterine horn of 89%, and in ovaries or oviducts of 100%. None of 
      the reproductive tissues of the male transgenic animals or age-matched, normal 
      mice displayed these changes. These results revealed a role for the EGFR in the 
      initiation of ovarian and uterine cancer and supported previous studies in breast 
      cancer that the receptor can contribute to the neoplastic process in a 
      significant albeit incremental way.
FAU - Marozkina, Nadzeya V
AU  - Marozkina NV
AD  - Department of Microbiology, University of Virginia Health System, 
      Charlottesville, Virginia 22908, USA.
FAU - Stiefel, Steven M
AU  - Stiefel SM
FAU - Frierson, Henry F Jr
AU  - Frierson HF Jr
FAU - Parsons, Sarah J
AU  - Parsons SJ
LA  - eng
GR  - R01CA071449/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Recombinant Fusion Proteins)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/metabolism/pathology
MH  - ErbB Receptors/*biosynthesis/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Mammary Glands, Animal/*pathology
MH  - Mammary Neoplasms, Experimental/*metabolism/pathology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Neoplasms, Hormone-Dependent/*metabolism/pathology
MH  - Ovary/metabolism/pathology
MH  - Precancerous Conditions/*metabolism/pathology
MH  - Prostate/metabolism/pathology
MH  - Recombinant Fusion Proteins/metabolism
MH  - Testis/metabolism/pathology
MH  - Uterus/metabolism/pathology
EDAT- 2007/10/26 09:00
MHDA- 2008/08/30 09:00
CRDT- 2007/10/26 09:00
PHST- 2007/10/26 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2007/10/26 09:00 [entrez]
AID - 10.1002/jcb.21591 [doi]
PST - ppublish
SO  - J Cell Biochem. 2008 Apr 15;103(6):2010-8. doi: 10.1002/jcb.21591.