PMID- 17961438
OWN - NLM
STAT- MEDLINE
DCOM- 20090811
LR  - 20181201
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 35
IP  - 7
DP  - 2007 Jul
TI  - [Atorvastatin inhibits scavenger receptor A and monocyte chemoattractant 
      protein-1 expressions in foam cell].
PG  - 666-9
AB  - OBJECTIVE: To investigate the effects of atorvastatin on expressions of scavenger 
      receptor A and secretion of monocyte chemoattractant protein-1 (MCP-1) in foam 
      cells. METHODS: THP-1 cells were induced to differentiate into macrophages by PMA 
      and treated with 0.1% BSA (control), ox-LDL (100 mg/L) or ox-LDL plus 
      atorvastatin (5, 10, 20 micromol/L) for 24 hours. MCP-1 concentration in cell 
      substratum was measured by ELISA. Scavenger receptor A expression was observed 
      under fluorescent microscope after incubated with DiI-Ac-LDL. The relationship 
      between concentration of MCP-1 and the activity of scavenger receptor A was also 
      analyzed. RESULTS: Compared to the control cells, MCP-1 concentration in ox-LDL 
      treated cells was significantly increased after 6 hours, peaked at 12 hours and 
      was still significantly increased after 24 hours (all P < 0.05 vs. baseline). The 
      activity of scavenger receptor A was also significantly increased in ox-LDL 
      treated cells (P < 0.01 vs. control). The activity of scavenger receptor A 
      proteins correlated positively to the concentration of MCP-1 in ox-LDL treated 
      cells (r = 0.683, P < 0.01). Atorvastatin significantly attenuated these changes 
      in a dose-dependent manner. CONCLUSIONS: Scavenger receptor A and MCP-1 
      expressions were significantly increased in the course of monocyte lines THP-1 
      differentiating into macrophages and foam cells. The anti-atherosclerosis effect 
      of atorvastatin might be partly achieved by inhibiting the secretion of MCP-1 and 
      expression of scavenger receptor A in foam cells.
FAU - Zhu, Gui-yue
AU  - Zhu GY
AD  - Department of Cardiology, Shandong Provincial Hospital, Shandong University, 
      Jinan 250021, China. zgymd@163.com
FAU - Zhu, Xing-lei
AU  - Zhu XL
FAU - Li, Ren-tiao
AU  - Li RT
FAU - Liu, Tong-bao
AU  - Liu TB
FAU - Shang, De-ya
AU  - Shang DY
FAU - Zhang, Yun
AU  - Zhang Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Pyrroles)
RN  - 0 (Scavenger Receptors, Class A)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
MH  - Atorvastatin
MH  - Cell Differentiation
MH  - Cell Line
MH  - Chemokine CCL2/*metabolism
MH  - Foam Cells/cytology/*drug effects/metabolism
MH  - Heptanoic Acids/*pharmacology
MH  - Humans
MH  - Monocytes/cytology/drug effects/metabolism
MH  - Pyrroles/*pharmacology
MH  - Scavenger Receptors, Class A/*metabolism
EDAT- 2007/10/27 09:00
MHDA- 2009/08/12 09:00
CRDT- 2007/10/27 09:00
PHST- 2007/10/27 09:00 [pubmed]
PHST- 2009/08/12 09:00 [medline]
PHST- 2007/10/27 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Jul;35(7):666-9.