PMID- 17961579
OWN - NLM
STAT- MEDLINE
DCOM- 20080613
LR  - 20090115
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1186
IP  - 1-2
DP  - 2008 Apr 4
TI  - Application of micro-solid-phase extraction for the determination of persistent 
      organic pollutants in tissue samples.
PG  - 358-64
AB  - A novel, simple and efficient method for determining persistent organic 
      pollutants (POPs) in tissue samples has been developed. This technique involves 
      the use of simultaneous microwave-assisted digestion (MAD) and micro-solid-phase 
      extraction (micro-SPE), in which the sorbent is held within a propylene membrane 
      envelope, with gas chromatographic-mass spectrometric (GC-MS) analysis. The POPs 
      studied included eleven organochlorine pesticides and five polychlorinated 
      biphenyl congeners. Optimization of the MAD-micro-SPE parameters was performed. 
      The relative standard deviations (RSDs) of the method ranged from 0.14 to 12.7%. 
      Correlation coefficients up to 0.9999 were obtained across a concentration range 
      of 1.25-50 ng g(-1). The method detection limits for POPs ranged from 0.002 to 
      0.009 ng g(-1). A preliminary study applying the MAD-micro-SPE procedure to human 
      ovarian cancer tissue showed that it was capable of detecting the presence of a 
      wide spectrum of different POPs in benign and malignant tumors.
FAU - Basheer, Chanbasha
AU  - Basheer C
AD  - Department of Chemistry, National University of Singapore, 3 Science Drive 3, 
      Singapore 117543, Singapore.
FAU - Narasimhan, Kothandaraman
AU  - Narasimhan K
FAU - Yin, Meihui
AU  - Yin M
FAU - Zhao, Changqing
AU  - Zhao C
FAU - Choolani, Mahesh
AU  - Choolani M
FAU - Lee, Hian Kee
AU  - Lee HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071011
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Solvents)
SB  - IM
MH  - Calibration
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - Humans
MH  - Microwaves
MH  - Organic Chemicals/*analysis
MH  - Ovarian Neoplasms/*chemistry
MH  - Ovary/*chemistry
MH  - Solid Phase Extraction/*methods
MH  - Solvents
MH  - Temperature
MH  - Time Factors
EDAT- 2007/10/27 09:00
MHDA- 2008/06/14 09:00
CRDT- 2007/10/27 09:00
PHST- 2007/06/25 00:00 [received]
PHST- 2007/10/02 00:00 [revised]
PHST- 2007/10/05 00:00 [accepted]
PHST- 2007/10/27 09:00 [pubmed]
PHST- 2008/06/14 09:00 [medline]
PHST- 2007/10/27 09:00 [entrez]
AID - S0021-9673(07)01728-1 [pii]
AID - 10.1016/j.chroma.2007.10.015 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Apr 4;1186(1-2):358-64. doi: 10.1016/j.chroma.2007.10.015. 
      Epub 2007 Oct 11.