PMID- 17962353
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20231105
IS  - 0013-7227 (Print)
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 149
IP  - 1
DP  - 2008 Jan
TI  - Food restriction alters neuronal morphology in the hypothalamic ventromedial 
      nucleus of male rats.
PG  - 93-9
AB  - Several lines of evidence have implicated the hypothalamic ventromedial nucleus 
      (VMH) in the control of caloric homeostasis. For example, the activity of VMH 
      neurons depends on energy availability. We tested the hypothesis that energy 
      balance may involve the remodeling of the dendritic arbor of VMH neurons. We 
      compared two groups of animals: one group had ad libitum access to food, and the 
      other experienced 10-d restricted access to food. As expected, the food-deprived 
      group lost body weight and had reduced levels of glucose, insulin, and leptin. 
      VMH neurons were visualized after Golgi impregnation, and dendrite length was 
      measured. Food deprivation had differential effects on VMH neurons. In 
      particular, within the ventrolateral VMH, for neurons with long primary dendrites 
      (LPDs) that extended in the lateral, but not medial, direction, the LPDs were 31% 
      shorter. These same neurons exhibited a 32% reduction in the number of other 
      dendrites without a change in soma size. In contrast, within the dorsomedial VMH, 
      for neurons with medially, but not laterally, extended LPDs, the soma area was 
      reduced by 28%. However, neurons in the dorsomedial VMH did not display a change 
      in the length or number of dendrites, regardless of LPD direction. Thus, although 
      structural changes during calorie depletion occur in both the dorsomedial and 
      ventrolateral VMH, only the latter exhibits a remodeled dendritic arbor. These 
      results also suggest that the direction of the LPD may be an important marker of 
      neuronal function in the VMH.
FAU - Flanagan-Cato, Loretta M
AU  - Flanagan-Cato LM
AD  - Department of Psychology, University of Pennsylvania, 3720 Walnut Street, 
      Philadelphia, Pennsylvania 19104-6241, USA. flanagan@psych.upenn.edu
FAU - Fluharty, Steven J
AU  - Fluharty SJ
FAU - Weinreb, Elena B
AU  - Weinreb EB
FAU - LaBelle, Denise R
AU  - LaBelle DR
LA  - eng
GR  - R01 DK052018/DK/NIDDK NIH HHS/United States
GR  - R01 MH064371/MH/NIMH NIH HHS/United States
GR  - MH64371/MH/NIMH NIH HHS/United States
GR  - DK52108/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20071025
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Hormones)
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - Cell Shape
MH  - Eating/physiology
MH  - Food Deprivation/*physiology
MH  - Hormones/blood
MH  - Male
MH  - Models, Biological
MH  - Neurons/*cytology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ventromedial Hypothalamic Nucleus/*cytology
PMC - PMC2194610
EDAT- 2007/10/27 09:00
MHDA- 2008/02/27 09:00
PMCR- 2009/01/01
CRDT- 2007/10/27 09:00
PHST- 2007/10/27 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/10/27 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - en.2007-0008 [pii]
AID - 3791 [pii]
AID - 10.1210/en.2007-0008 [doi]
PST - ppublish
SO  - Endocrinology. 2008 Jan;149(1):93-9. doi: 10.1210/en.2007-0008. Epub 2007 Oct 25.