PMID- 17963454
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 45
IP  - 12
DP  - 2007
TI  - Management of L-Dopa related hyperhomocysteinemia: catechol-O-methyltransferase 
      (COMT) inhibitors or B vitamins? Results from a review.
PG  - 1607-13
AB  - In recent years, L-Dopa treatment has been indicated as an acquired cause of 
      hyperhomocysteinemia (HHcy). The mechanism underlying L-Dopa-related HHcy is the 
      O-methylation of the drug catalyzed by the enzyme catechol-O-methyltransferase 
      (COMT). Folate and cobalamin status also influences the effects of L-Dopa on 
      plasma homocysteine (Hcy) levels. Although clinical correlations of HHcy in 
      Parkinson's disease still remain uncertain, management of elevated plasma Hcy 
      levels has been advocated, due to multiple cytotoxic effects of Hcy on neurons. 
      This review summarizes data available in the literature concerning the two main 
      therapeutic approaches to L-Dopa-related HHcy (use of COMT inhibitors or B 
      vitamins diet supplementation).
FAU - Zoccolella, Stefano
AU  - Zoccolella S
AD  - Department of Neurological Sciences, University of Bari, Bari, Italy.
FAU - Iliceto, Giovanni
AU  - Iliceto G
FAU - deMari, Michele
AU  - deMari M
FAU - Livrea, Paolo
AU  - Livrea P
FAU - Lamberti, Paolo
AU  - Lamberti P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Catechol O-Methyltransferase Inhibitors)
RN  - 0 (Enzyme Inhibitors)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - *Catechol O-Methyltransferase Inhibitors
MH  - Enzyme Inhibitors/*pharmacology
MH  - Humans
MH  - Hyperhomocysteinemia/*chemically induced
MH  - Levodopa/*adverse effects
MH  - Vitamin B Complex/*pharmacology
RF  - 49
EDAT- 2007/10/30 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/10/30 09:00
PHST- 2007/10/30 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/10/30 09:00 [entrez]
AID - 10.1515/CCLM.2007.337 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2007;45(12):1607-13. doi: 10.1515/CCLM.2007.337.