PMID- 17963506 OWN - NLM STAT- MEDLINE DCOM- 20080219 LR - 20211020 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 7 DP - 2007 Oct 26 TI - Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study. PG - 30 AB - BACKGROUND: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. METHODS: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. RESULTS: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC > 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95% confidence interval [CI]: 0.91-1.63), 1.15 (0.84-1.58), 1.49 (1.09-2.05), and 1.72 (1.26-2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92-1.73), 0.99 (0.73-1.34), 1.42 (1.03-1.96), and 2.00 (1.43-2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64-2.08) and 1.25 (0.70-2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC > or = 10 was analyzed as an outcome for both MCP-1 and sICAM-1. CONCLUSION: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors. FAU - Tang, Weihong AU - Tang W AD - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. tang0097@umn.edu FAU - Pankow, James S AU - Pankow JS FAU - Carr, J Jeffrey AU - Carr JJ FAU - Tracy, Russell P AU - Tracy RP FAU - Bielinski, Suzette J AU - Bielinski SJ FAU - North, Kari E AU - North KE FAU - Hopkins, Paul N AU - Hopkins PN FAU - Kraja, Aldi T AU - Kraja AT FAU - Arnett, Donna K AU - Arnett DK LA - eng GR - U01 HL67899/HL/NHLBI NIH HHS/United States GR - U01 HL56564/HL/NHLBI NIH HHS/United States GR - U01 HL67897/HL/NHLBI NIH HHS/United States GR - R01 AR048797/AR/NIAMS NIH HHS/United States GR - M01 RR007122-150204/RR/NCRR NIH HHS/United States GR - U01 HL56569/HL/NHLBI NIH HHS/United States GR - U01 HL067900/HL/NHLBI NIH HHS/United States GR - U01 HL067898/HL/NHLBI NIH HHS/United States GR - U01 HL67900/HL/NHLBI NIH HHS/United States GR - U01 HL067894/HL/NHLBI NIH HHS/United States GR - U01 HL67895/HL/NHLBI NIH HHS/United States GR - U01 HL067899/HL/NHLBI NIH HHS/United States GR - U01 HL56567/HL/NHLBI NIH HHS/United States GR - U01 HL67898/HL/NHLBI NIH HHS/United States GR - U01 HL56563/HL/NHLBI NIH HHS/United States GR - U01 HL 67893/HL/NHLBI NIH HHS/United States GR - U01 HL067902/HL/NHLBI NIH HHS/United States GR - U01 HL56565/HL/NHLBI NIH HHS/United States GR - U01 HL067897/HL/NHLBI NIH HHS/United States GR - M01 RR007122-140204/RR/NCRR NIH HHS/United States GR - U01 HL067893/HL/NHLBI NIH HHS/United States GR - R01 AR048797-03/AR/NIAMS NIH HHS/United States GR - U01 HL056567/HL/NHLBI NIH HHS/United States GR - U01 HL67896/HL/NHLBI NIH HHS/United States GR - U01 HL067896/HL/NHLBI NIH HHS/United States GR - U01 HL56566/HL/NHLBI NIH HHS/United States GR - U01 HL067901/HL/NHLBI NIH HHS/United States GR - R01 AR048797-02/AR/NIAMS NIH HHS/United States GR - U01 HL67902./HL/NHLBI NIH HHS/United States GR - R01 AR048797-01/AR/NIAMS NIH HHS/United States GR - U01 HL56568/HL/NHLBI NIH HHS/United States GR - M01 RR007122/RR/NCRR NIH HHS/United States GR - U01 HL067895/HL/NHLBI NIH HHS/United States GR - M01 RR007122-130204/RR/NCRR NIH HHS/United States GR - R01 AR048797-04/AR/NIAMS NIH HHS/United States GR - U01 HL67894/HL/NHLBI NIH HHS/United States GR - U01 HL67901/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20071026 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0 (Biomarkers) RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) RN - 126547-89-5 (Intercellular Adhesion Molecule-1) SB - IM MH - Biomarkers/blood MH - Calcinosis/*blood MH - Chemokine CCL2/*blood MH - Coronary Artery Disease/*blood MH - Coronary Vessels/metabolism MH - Female MH - Follow-Up Studies MH - Humans MH - Hypertension/blood MH - Intercellular Adhesion Molecule-1/*blood MH - Male MH - Middle Aged MH - Tomography, X-Ray Computed PMC - PMC2204036 EDAT- 2007/10/30 09:00 MHDA- 2008/02/20 09:00 PMCR- 2007/10/26 CRDT- 2007/10/30 09:00 PHST- 2007/06/19 00:00 [received] PHST- 2007/10/26 00:00 [accepted] PHST- 2007/10/30 09:00 [pubmed] PHST- 2008/02/20 09:00 [medline] PHST- 2007/10/30 09:00 [entrez] PHST- 2007/10/26 00:00 [pmc-release] AID - 1471-2261-7-30 [pii] AID - 10.1186/1471-2261-7-30 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2007 Oct 26;7:30. doi: 10.1186/1471-2261-7-30.