PMID- 17964975
OWN - NLM
STAT- MEDLINE
DCOM- 20080903
LR  - 20151119
IS  - 1148-5493 (Print)
IS  - 1148-5493 (Linking)
VI  - 18
IP  - 4
DP  - 2007 Dec
TI  - Ibuprofen does not affect levels of tumor necrosis factor alpha and soluble tumor 
      necrosis factor receptor types I and II in Gabonese children with uncomplicated 
      Plasmodium falciparum malaria.
PG  - 201-5
AB  - We assessed the ability of ibuprofen to modulate tumor necrosis factor alpha 
      (TNF-alpha), soluble tumor necrosis factor receptor type I (sTNFR-I), and soluble 
      tumor necrosis factor receptor type II (sTNFR-II) responses during the treatment 
      of fever in uncomplicated Plasmodium falciparum malaria, in a placebo-controlled, 
      randomized, double-blind study of 50 pediatric patients in Lambarene, Gabon. 
      Treatment of the malaria involved the patients receiving intravenous quinine (12 
      mg/kg of quinine dihydrochloride every 12 h for 72 h) followed by a single dose 
      of oral sulfadoxine/pyrimethamine (25 mg and 1.25 mg/kg). Fever was treated by 
      mechanical treatment plus either ibuprofen (7 mg/kg every 8 h) or placebo during 
      the hospitalization period. We determined serum concentrations of TNF-alpha, 
      sTNFR-I, and sTNFR-II in peripheral blood throughout the treatment period in the 
      two groups: ibuprofen and placebo groups. TNF-alpha levels were found to be 
      positively correlated with body temperature. In contrast, TNF receptors levels 
      did not differ between the two groups and the antipyretic effect of ibuprofen was 
      not correlated with specific changes in sTNFR-I and sTNFR-II production. Our data 
      suggest that TNF-alpha is involved in malarial fever, but soluble TNF receptors 
      play no major role in fever modulation.
FAU - Matsiegui, Pierre-Blaise
AU  - Matsiegui PB
AD  - Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon.
FAU - Missinou, Michel A
AU  - Missinou MA
FAU - Issifou, Saadou
AU  - Issifou S
FAU - Necek, Magdalena
AU  - Necek M
FAU - Mavoungou, Elie
AU  - Mavoungou E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20071026
PL  - France
TA  - Eur Cytokine Netw
JT  - European cytokine network
JID - 9100879
RN  - 0 (Antimalarials)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Placebos)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 88463U4SM5 (Sulfadoxine)
RN  - A7V27PHC7A (Quinine)
RN  - OP401G7OJC (Etanercept)
RN  - WK2XYI10QM (Ibuprofen)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
MH  - Animals
MH  - Antimalarials/*administration & dosage
MH  - Child
MH  - Double-Blind Method
MH  - Etanercept
MH  - Gabon
MH  - Humans
MH  - Ibuprofen/*pharmacology
MH  - Immunoglobulin G/*biosynthesis
MH  - Malaria, Falciparum/*blood/parasitology
MH  - Placebos
MH  - Plasmodium falciparum/*metabolism
MH  - Pyrimethamine/*administration & dosage
MH  - Quinine/*administration & dosage
MH  - Receptors, Tumor Necrosis Factor/*biosynthesis
MH  - Receptors, Tumor Necrosis Factor, Type II/*biosynthesis
MH  - Sulfadoxine/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/metabolism
EDAT- 2007/10/30 09:00
MHDA- 2008/09/04 09:00
CRDT- 2007/10/30 09:00
PHST- 2007/10/15 00:00 [accepted]
PHST- 2007/10/30 09:00 [pubmed]
PHST- 2008/09/04 09:00 [medline]
PHST- 2007/10/30 09:00 [entrez]
AID - ecn.2007.0105 [pii]
AID - 10.1684/ecn.2007.0105 [doi]
PST - ppublish
SO  - Eur Cytokine Netw. 2007 Dec;18(4):201-5. doi: 10.1684/ecn.2007.0105. Epub 2007 
      Oct 26.