PMID- 17965799
OWN - NLM
STAT- MEDLINE
DCOM- 20080221
LR  - 20080623
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 28
IP  - 11
DP  - 2007 Nov
TI  - Association of breast cancer and cytokine gene polymorphism in Turkish women.
PG  - 1728-33
AB  - OBJECTIVE: To investigate the association of cytokine gene polymorphism with the 
      development of breast cancer. METHODS: The study was carried out in Uludag 
      University Medical School, Bursa, Turkey. The study included 38 patients with 
      breast cancer admitted to the Medical Oncology outpatient clinic, and 24 healthy 
      controls, age and sex matched, from the Internal Medicine Department between 2004 
      and 2005. All genotyping of tumor necrosis factor-alpha (TNF-alpha), tumor growth 
      factor-beta1 (TGF-beta1), interleukin (IL)-10, IL-6, and interferon-gamma 
      (IFN-gamma) experiments were performed using polymerase chain reaction 
      sequence-specific primers. RESULTS: The frequencies of IL-6-174GC genotype and 
      IL-10 (-1082, -819, -592) GCC/ATA haplotype were significantly higher in the 
      patient group (p=0.0008) when compared with controls (p=0.020). Significantly 
      lower frequencies of IL-10 (-1082, -819, -592) ACC/ATA haplotype were observed in 
      the patient group in comparison to the controls (p=0.026). The distribution of 
      IFN-gamma +874, TNF-alpha 308, and TGF-beta1 codon 10-25 genotypes failed to show 
      any statistical significant association with the development of breast cancer. 
      CONCLUSION: Our data suggest that IL-10 (-1082, -819, -592) GCC/ATA haplotype and 
      IL-6-174 GC genotype seem to be potential risk factors for the development of 
      breast cancer. The presence of IL-10ACC/ATA haplotype may be protective for the 
      oncogenesis of breast cancer.
FAU - Gonullu, Guzin
AU  - Gonullu G
AD  - Department of Medical Oncology, Ondokuz Mayis University Medical School, 
      Kurupelit, Samsun, Turkey. ggonullu@omu.edu.tr
FAU - Basturk, Bilkay
AU  - Basturk B
FAU - Evrensel, Turkkan
AU  - Evrensel T
FAU - Oral, Barboros
AU  - Oral B
FAU - Gozkaman, Ayse
AU  - Gozkaman A
FAU - Manavoglu, Osman
AU  - Manavoglu O
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Codon)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Codon
MH  - Cytokines/*genetics
MH  - Female
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-10/genetics
MH  - Interleukin-6/genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Transforming Growth Factor beta/genetics
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Turkey/epidemiology
EDAT- 2007/10/30 09:00
MHDA- 2008/02/22 09:00
CRDT- 2007/10/30 09:00
PHST- 2007/10/30 09:00 [pubmed]
PHST- 2008/02/22 09:00 [medline]
PHST- 2007/10/30 09:00 [entrez]
AID - 20070316' [pii]
PST - ppublish
SO  - Saudi Med J. 2007 Nov;28(11):1728-33.