PMID- 17967414
OWN - NLM
STAT- MEDLINE
DCOM- 20071218
LR  - 20181201
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 364
IP  - 4
DP  - 2007 Dec 28
TI  - Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 
      adipocytes.
PG  - 972-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in adipose 
      tissues of obese rodents and humans. Increased levels of TNF-alpha are implicated 
      in the induction of atherogenic adipokines, such as plasminogen activator 
      inhibitor -1 (PAI-1) and IL-6, and the inhibition of the anti-atherogenic 
      adipokine, adiponectin. In this study, we investigated the effects of resveratrol 
      on TNF-alpha-induced atherogenic changes of the adipokines in 3T3-L1 cells. 
      Exposure to TNF-alpha for 24 h increased PAI-1 and IL-6 secretion and decreased 
      adiponectin secretion. The mRNA expression of adipokines changed in parallel with 
      mRNA expression. Resveratrol effectively reversed the secretion and mRNA 
      expression of the atherogenic adipokines, PAI-1 and IL-6, induced by TNF-alpha. 
      Decreased secretion levels and mRNA expression of adiponectin by TNF-alpha were 
      also recovered by resveratrol treatment. Our results suggest that resveratrol may 
      improve obesity-induced cardiovascular disease, particularly atherosclerosis, by 
      attenuating the TNF-alpha-induced changes of adipokines.
FAU - Ahn, Jiyun
AU  - Ahn J
AD  - Food Function Research Group, Korea Food Research Institute, 516, Baekhyun-dong, 
      Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
FAU - Lee, Hyunjung
AU  - Lee H
FAU - Kim, Suna
AU  - Kim S
FAU - Ha, Taeyoul
AU  - Ha T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071029
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Adiponectin)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Serpin E2)
RN  - 0 (Serpine2 protein, mouse)
RN  - 0 (Serpins)
RN  - 0 (Stilbenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vasodilator Agents)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/drug effects/*metabolism
MH  - Adiponectin/*metabolism
MH  - Animals
MH  - Cytokines/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Interleukin-6/*metabolism
MH  - Mice
MH  - Resveratrol
MH  - Serpin E2
MH  - Serpins/*metabolism
MH  - Stilbenes/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/*administration & dosage
MH  - Vasodilator Agents/administration & dosage
EDAT- 2007/10/31 09:00
MHDA- 2007/12/19 09:00
CRDT- 2007/10/31 09:00
PHST- 2007/10/05 00:00 [received]
PHST- 2007/10/18 00:00 [accepted]
PHST- 2007/10/31 09:00 [pubmed]
PHST- 2007/12/19 09:00 [medline]
PHST- 2007/10/31 09:00 [entrez]
AID - S0006-291X(07)02279-6 [pii]
AID - 10.1016/j.bbrc.2007.10.109 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Dec 28;364(4):972-7. doi: 
      10.1016/j.bbrc.2007.10.109. Epub 2007 Oct 29.