PMID- 17970077
OWN - NLM
STAT- MEDLINE
DCOM- 20071127
LR  - 20071031
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 27
IP  - 5A
DP  - 2007 Sep-Oct
TI  - Resampling based on geographic patterns of hepatitis virus infection reveals a 
      common gene signature for early intrahepatic recurrence of hepatocellular 
      carcinoma.
PG  - 3323-30
AB  - The majority of hepatocellular carcinomas (HCCs) correlated with infection by 
      either hepatitis B or C virus (HBV or HCV) showing various geographic 
      distributions, making it impossible to identify common gene signatures 
      responsible for HCC recurrence. In this study we performed in silico resampling 
      analysis of DNA microarray data that can reproduce virtually the geographic 
      distribution pattern of HBV and HCV in 6 representative geographic regions. With 
      the use of the Fisher ratio, genes associated with early intrahepatic recurrence 
      of HCC within 1 year of surgery were identified in the 6 geographic virtual 
      cohorts, each consisting of 1,000 virtual samples. The top 100 genes among each 
      virtual cohort were compared. Many human leukocyte antigen (HLA) family genes 
      were common among the 6 geographic virtual cohorts, suggesting that this gene 
      family represents the pathway most responsible for early intrahepatic recurrence 
      of HCC worldwide. This resampling approach is useful for identifying common 
      pathways involved in various aspects of HCC.
FAU - Uchimura, Shunji
AU  - Uchimura S
AD  - Department of Computer Science and Systems Engineering, Faculty of Engineering, 
      Yamaguchi University, Yamaguchi, Japan.
FAU - Iizuka, Norio
AU  - Iizuka N
FAU - Tamesa, Takao
AU  - Tamesa T
FAU - Miyamoto, Takanobu
AU  - Miyamoto T
FAU - Hamamoto, Yoshihiko
AU  - Hamamoto Y
FAU - Oka, Masaaki
AU  - Oka M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Carcinoma, Hepatocellular/epidemiology/*genetics/virology
MH  - HLA Antigens/genetics
MH  - Hepacivirus/genetics
MH  - Hepatitis B/epidemiology/*genetics
MH  - Hepatitis B virus/genetics
MH  - Hepatitis C/epidemiology/*genetics
MH  - Humans
MH  - Liver Neoplasms/epidemiology/*genetics/virology
MH  - Neoplasm Recurrence, Local/*genetics/virology
MH  - Oligonucleotide Array Sequence Analysis
EDAT- 2007/11/01 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2007 Sep-Oct;27(5A):3323-30.