PMID- 17970717
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20200930
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 38
IP  - 1
DP  - 2008 Jan
TI  - Human leukocyte antigen DR status and clinical features in Japanese patients with 
      type 1 autoimmune hepatitis.
PG  - 96-102
AB  - AIM: Human leukocyte antigen (HLA) DR status affects the clinical features of 
      autoimmune hepatitis. In Caucasians, patients with DR3 have poorer outcomes. In 
      Japan, the relationship between HLA DR status and clinical features has yet to be 
      fully examined. METHODS: We investigated 79 patients with type 1 autoimmune 
      hepatitis who underwent liver biopsy and were screened for HLA DR status by the 
      polymerase chain reaction sequence specific oligonucleotide hybridization method. 
      RESULTS: Fifty-five patients had DR4 and 23 had DR2. Thirteen patients had both 
      DR2 and DR4. None had DR3. Of patients aged <30 years, 70% did not have DR4. A 
      tendency toward higher serum levels of immunoglobulin G was seen in patients with 
      DR4 compared to those without, while patients with neither DR2 nor DR4 had lower 
      serum levels of immunoglobulin G than those with only DR2 and those with only 
      DR4. Patients with DR2 had a lower frequency of concurrentautoimmune disease. 
      Concurrence of thyroid disease was seen only in patients with DR4. The cumulative 
      incidental rate of the normalization of serum alanine aminotransferase levels 
      within six months after the introduction of corticosteroid treatment was not 
      associated with HLA DR status. CONCLUSION: HLA DR status is considered to affect 
      the clinical features of Japanese patients with type 1 autoimmune hepatitis. 
      Japanese patients with DR2 may have different clinical features from others. In 
      addition, diagnoses of type 1 autoimmune hepatitis should be made carefully in 
      Japanese patients with neither DR2 nor DR4 and in those aged <30 years.
FAU - Miyake, Yasuhiro
AU  - Miyake Y
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Iwasaki, Yoshiaki
AU  - Iwasaki Y
FAU - Takaki, Akinobu
AU  - Takaki A
FAU - Onishi, Toru
AU  - Onishi T
FAU - Okamoto, Ryoichi
AU  - Okamoto R
FAU - Takaguchi, Kouichi
AU  - Takaguchi K
FAU - Ikeda, Hiroshi
AU  - Ikeda H
FAU - Makino, Yasuhiro
AU  - Makino Y
FAU - Kobashi, Haruhiko
AU  - Kobashi H
FAU - Sakaguchi, Kohsaku
AU  - Sakaguchi K
FAU - Shiratori, Yasushi
AU  - Shiratori Y
LA  - eng
PT  - Journal Article
DEP - 20071029
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
EDAT- 2007/11/01 09:00
MHDA- 2007/11/01 09:01
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2007/11/01 09:01 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - HEP204 [pii]
AID - 10.1111/j.1872-034X.2007.00204.x [doi]
PST - ppublish
SO  - Hepatol Res. 2008 Jan;38(1):96-102. doi: 10.1111/j.1872-034X.2007.00204.x. Epub 
      2007 Oct 29.