PMID- 17970744
OWN - NLM
STAT- MEDLINE
DCOM- 20080314
LR  - 20191210
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 26
IP  - 9
DP  - 2007 Nov
TI  - Lesions of rat infralimbic cortex result in disrupted retardation but normal 
      summation test performance following training on a Pavlovian conditioned 
      inhibition procedure.
PG  - 2654-60
AB  - The prefrontal cortex has a well-established role in the inhibition of 
      inappropriate responding. Converging evidence implicates the infralimbic (IL) 
      region of the rat medial prefrontal cortex (MPFC) in the maintenance of 
      extinction [Quirk et al. (2000)J. Neurosci., 20, 6225-6231; Rhodes & Killcross 
      (2004)Learn. Mem., 11, 611-616], a process generally considered to be mediated by 
      the formation of inhibitory associations. An appetitive Pavlovian conditioned 
      inhibition paradigm was used in order to investigate further the role of the IL 
      MPFC in the control over behaviour by inhibitory associations. In two separate 
      experiments, the effect of IL lesions on summation and retardation tests of 
      conditioned inhibition was assessed. IL lesions did not affect summation test 
      performance, indicating that lesioned animals were able to acquire inhibitory 
      associations between a stimulus and reward and could express them normally when 
      placed in competition with an excitatory cue. However, the retardation of 
      excitatory conditioning that is normally seen when a stimulus with inhibitory 
      properties is subsequently paired with reward was abolished in IL-lesioned 
      animals. This suggests a selective role for the IL MPFC in the competition for 
      behavioural control between the inhibitory and excitatory associations of a 
      single stimulus.
FAU - Rhodes, S E V
AU  - Rhodes SE
AD  - School of Psychology, Cardiff University, Cardiff CF10 3AT, UK. 
      RhodesS@cardiff.ac.uk
FAU - Killcross, A S
AU  - Killcross AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071026
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/physiology
MH  - Association Learning/*physiology
MH  - Cognition/*physiology
MH  - Conditioning, Classical/*physiology
MH  - Cues
MH  - Denervation
MH  - Discrimination Learning/physiology
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Extinction, Psychological/*physiology
MH  - Inhibitory Postsynaptic Potentials/physiology
MH  - Learning Disabilities/etiology/physiopathology
MH  - Male
MH  - Neural Inhibition/*physiology
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/injuries/*physiopathology
MH  - Rats
MH  - Reinforcement, Psychology
MH  - Reversal Learning/physiology
MH  - Reward
EDAT- 2007/11/01 09:00
MHDA- 2008/03/15 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/03/15 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - EJN5855 [pii]
AID - 10.1111/j.1460-9568.2007.05855.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 Nov;26(9):2654-60. doi: 10.1111/j.1460-9568.2007.05855.x. 
      Epub 2007 Oct 26.