PMID- 17970779
OWN - NLM
STAT- MEDLINE
DCOM- 20090730
LR  - 20080222
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 68
IP  - 3
DP  - 2008 Mar
TI  - Serum total and high molecular weight adiponectin levels are correlated with the 
      severity of diabetic retinopathy and nephropathy.
PG  - 442-9
AB  - OBJECTIVE: Adiponectin is secreted specifically from adipocytes, and improves 
      insulin sensitivity. Of its isoforms, the high molecular weight (HMW) complex is 
      thought to be the most active. The aim of this study was to determine the 
      relationship between serum total or HMW adiponectin and diabetic microangiopathy. 
      DESIGN, PATIENTS AND MEASUREMENTS: We analysed 198 Japanese patients with type 2 
      diabetes mellitus (T2DM) whose fasting serum samples were available. Serum total 
      adiponectin and HMW adiponectin were measured using an enzyme-linked 
      immunosorbent assay (ELISA). RESULTS: Serum total adiponectin was found to have 
      increased in the advanced stages of diabetic retinopathy (mean +/- SE, none, 6.9 
      +/- 0.3; simple, 8.3 +/- 1.0; preproliferative, 8.4 +/- 0.8; proliferative, 12 
      +/- 1.1 mg/l; anovaP = 0.0004) and nephropathy (stage I, 7.0 +/- 0.3; II, 7.7 +/- 
      0.5; III, 9.5 +/- 0.9; IV, 16 +/- 4.5 mg/l, P < 0.0001). Similarly, serum HMW 
      adiponectin had increased in the advanced stages of retinopathy (3.7 +/- 0.2, 4.6 
      +/- 0.5, 4.6 +/- 0.6 and 6.9 +/- 0.8 mg/l, respectively, P = 0.0005) and 
      nephropathy (3.7 +/- 0.2, 4.3 +/- 0.4, 5.3 +/- 0.7 and 7.9 +/- 2.2 mg/l, 
      respectively, P = 0.0007). Neither serum total nor HMW adiponectin was correlated 
      with neuropathy. The HMW/total adiponectin ratio was not correlated with 
      microangiopathy. Multiple regression analysis revealed that serum total and HMW 
      adiponectin were independent factors for retinopathy stage (P = 0.0055 and P = 
      0.0027, respectively) and nephropathy stage (P = 0.0003 and P = 0.0018, 
      respectively), when adjusted for age, gender, body mass index (BMI) and the 
      duration of T2DM. This correlation remained significant when serum creatinine (or 
      estimated glomerular filtration rate) and hypertension were added as independent 
      variables. Treatment with thiazolidinediones (TZDs) did not affect these 
      findings. CONCLUSIONS: Serum total adiponectin and HMW adiponectin were found to 
      be positively correlated with the severity of retinopathy and nephropathy but not 
      with neuropathy in T2DM.
FAU - Kato, Kenichi
AU  - Kato K
AD  - Ehime Prefectural Hospital, Ehime, Japan.
FAU - Osawa, Haruhiko
AU  - Osawa H
FAU - Ochi, Masaaki
AU  - Ochi M
FAU - Kusunoki, Yukiko
AU  - Kusunoki Y
FAU - Ebisui, Osamu
AU  - Ebisui O
FAU - Ohno, Keizo
AU  - Ohno K
FAU - Ohashi, Jun
AU  - Ohashi J
FAU - Shimizu, Ikki
AU  - Shimizu I
FAU - Fujii, Yasuhisa
AU  - Fujii Y
FAU - Tanimoto, Mitsune
AU  - Tanimoto M
FAU - Makino, Hideichi
AU  - Makino H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071029
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*blood/chemistry
MH  - Aged
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Diabetic Nephropathies/blood/*diagnosis
MH  - Diabetic Retinopathy/blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
EDAT- 2007/11/01 09:00
MHDA- 2009/07/31 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2009/07/31 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - CEN3063 [pii]
AID - 10.1111/j.1365-2265.2007.03063.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2008 Mar;68(3):442-9. doi: 
      10.1111/j.1365-2265.2007.03063.x. Epub 2007 Oct 29.