PMID- 17970824
OWN - NLM
STAT- MEDLINE
DCOM- 20080116
LR  - 20161124
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 63
IP  - 1
DP  - 2008 Jan
TI  - The association of asthma, atopy and lung function with hormone replacement 
      therapy and surgical cessation of menstruation in a population-based sample of 
      English women.
PG  - 95-102
AB  - BACKGROUND: Gynaecological surgery that may lead to cessation of menstruation is 
      a major indication for the use of hormone replacement therapy (HRT) which in turn 
      has been associated with asthma. METHODS: Information on asthma-like symptoms, 
      lung function and immunoglobulin E (IgE) sensitization to house dust mite (HDM) 
      and on menstrual status and use of HRT was collected from 3724 women aged between 
      35 and 64 years living in England. Association of health outcomes with use of HRT 
      and with surgery resulting in cessation of menstruation was examined in 
      multivariable models. RESULTS: Over a third of women who had ever used HRT had 
      undergone surgery resulting in cessation of menstruation. Current use of HRT was 
      associated with frequent wheeze, particularly in lean women [body mass index 
      (BMI) < 25; odds ratio (OR) 1.90; 95% confidence interval (CI) 1.17-3.05; BMI 
      25+; OR 1.02; 95% CI 0.69-1.51]. Wheeze was associated with the reporting of 
      menstrual cessation that was due to surgery even if women denied ever using HRT 
      (OR 1.55; 95% CI 1.09-2.20). There was some evidence that HRT use was associated 
      with airway obstruction in leaner women but little evidence that it was 
      associated with IgE sensitization to HDM. CONCLUSIONS: In this cross-sectional 
      study use of HRT was associated with asthma-like symptoms, particularly in those 
      who have lower BMI. A substantial proportion of women whose periods have stopped 
      because of surgery use HRT but this does not fully explain their increased 
      morbidity.
FAU - Jarvis, D
AU  - Jarvis D
AD  - Department of Respiratory Epidemiology and Public Health, National Heart and Lung 
      Institute, Imperial College London, London, UK.
FAU - Leynaert, B
AU  - Leynaert B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071029
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Age of Onset
MH  - Asthma/*chemically induced/epidemiology/physiopathology
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Surveys
MH  - Hormone Replacement Therapy/*adverse effects/methods
MH  - Humans
MH  - Hypersensitivity, Immediate/*chemically induced/epidemiology/physiopathology
MH  - Hysterectomy/*adverse effects
MH  - Incidence
MH  - Menopause/drug effects
MH  - Middle Aged
MH  - Prognosis
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Sampling Studies
MH  - Severity of Illness Index
MH  - United Kingdom/epidemiology
EDAT- 2007/11/01 09:00
MHDA- 2008/01/17 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/01/17 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - ALL1530 [pii]
AID - 10.1111/j.1398-9995.2007.01530.x [doi]
PST - ppublish
SO  - Allergy. 2008 Jan;63(1):95-102. doi: 10.1111/j.1398-9995.2007.01530.x. Epub 2007 
      Oct 29.