PMID- 17971048
OWN - NLM
STAT- MEDLINE
DCOM- 20080430
LR  - 20071221
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 1
DP  - 2008 Jan
TI  - SNP mapping and candidate gene sequencing in the class I region of the HLA 
      complex: searching for multiple sclerosis susceptibility genes in Tasmanians.
PG  - 42-50
AB  - This study is an extension to previously published work that has linked variation 
      in the human leukocyte antigen (HLA) class I region with susceptibility to 
      multiple sclerosis (MS) in Australians from the Island State of Tasmania. Single 
      nucleotide polymorphism (SNP) mapping was performed on an 865-kb candidate region 
      (D6S1683-D6S265) in 166 Tasmanian MS families, and seven candidate genes 
      [ubiquitin D (UBD), olfactory receptor 2H3 (OR2H3), gamma-aminobutyric acid B 
      receptor 1 (GABBR1), myelin oligodendrocyte glycoprotein (MOG), HLA-F, HLA 
      complex group 4 (HCG4) and HLA-G] were resequenced. SNPs tagging the extended MS 
      susceptibility haplotype were genotyped in an independent sample of 356 
      Australian MS trios and SNPs in the MOG gene were significantly over-transmitted 
      to MS cases. We identified significant effects on MS susceptibility of HLA-A*2 
      (OR: 0.51; P = 0.05) and A*3 (OR: 2.85; P = 0.005), and two coding polymorphisms 
      in the MOG gene (V145I: P = 0.01, OR: 2.2; V142L: P = 0.04, OR: 0.45) after full 
      conditioning on HLA-DRB1. We have therefore identified plausible candidates for 
      the causal MS susceptibility allele, and although not conclusive at this stage, 
      our data provide suggestive evidence for multiple class I MS susceptibility 
      genes.
FAU - Burfoot, R K
AU  - Burfoot RK
AD  - Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia.
FAU - Jensen, C J
AU  - Jensen CJ
FAU - Field, J
AU  - Field J
FAU - Stankovich, J
AU  - Stankovich J
FAU - Varney, M D
AU  - Varney MD
FAU - Johnson, L J
AU  - Johnson LJ
FAU - Butzkueven, H
AU  - Butzkueven H
FAU - Booth, D
AU  - Booth D
FAU - Bahlo, M
AU  - Bahlo M
FAU - Tait, B D
AU  - Tait BD
FAU - Taylor, B V
AU  - Taylor BV
FAU - Speed, T P
AU  - Speed TP
FAU - Heard, R
AU  - Heard R
FAU - Stewart, G J
AU  - Stewart GJ
FAU - Foote, S J
AU  - Foote SJ
FAU - Kilpatrick, T J
AU  - Kilpatrick TJ
FAU - Rubio, J P
AU  - Rubio JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071030
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Case-Control Studies
MH  - *Chromosome Mapping
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Multiple Sclerosis/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - *Sequence Analysis, DNA
MH  - Tasmania
EDAT- 2007/11/01 09:00
MHDA- 2008/05/01 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/05/01 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - TAN962 [pii]
AID - 10.1111/j.1399-0039.2007.00962.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jan;71(1):42-50. doi: 10.1111/j.1399-0039.2007.00962.x. 
      Epub 2007 Oct 30.