PMID- 17971055
OWN - NLM
STAT- MEDLINE
DCOM- 20080430
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 1
DP  - 2008 Jan
TI  - HLA-G polymorphism in a Polish population and reproductive failure.
PG  - 67-71
AB  - To investigate whether human leukocyte antigen (HLA)-G gene polymorphism is 
      associated with reproductive failure in a Polish population, we sequenced exons 
      2-4 of the HLA-G gene in 58 couples with three recurrent spontaneous abortions 
      (RSAs) in the first trimester of pregnancy and 58 fertile control couples. We 
      identified 12 different HLA-G alleles. Neither allele was found to be associated 
      with an increased risk of RSA in the population. HLA-G allele sharing was similar 
      in couples with RSA and in control fertile couples. All cases and controls were 
      also genotyped for the -725C>G polymorphisms in the promoter region and the 14-bp 
      insertion deletion in the 3' untranslated region of the HLA-G gene. The 
      frequencies of both variants in RSA women and control fertile women were similar. 
      These results suggest that HLA-G gene polymorphism does not influence the risk of 
      RSA in the Polish population, but further studies are needed in this regard.
FAU - Sipak-Szmigiel, O
AU  - Sipak-Szmigiel O
AD  - Department of Feto-Maternal Medicine, Pomeranian Medical University, Szczecin, 
      Poland. olimpiasipak-szmigiel@wp.pl
FAU - Cybulski, C
AU  - Cybulski C
FAU - Lubinski, J
AU  - Lubinski J
FAU - Ronin-Walknowska, E
AU  - Ronin-Walknowska E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071029
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - Male
MH  - Poland
MH  - *Polymorphism, Genetic
MH  - Pregnancy
EDAT- 2007/11/01 09:00
MHDA- 2008/05/01 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/05/01 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - TAN942 [pii]
AID - 10.1111/j.1399-0039.2007.00942.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jan;71(1):67-71. doi: 10.1111/j.1399-0039.2007.00942.x. 
      Epub 2007 Oct 29.