PMID- 17971177
OWN - NLM
STAT- MEDLINE
DCOM- 20080416
LR  - 20221207
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 24
IP  - 12
DP  - 2007 Dec
TI  - Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of 
      pancreatic B-cells 12 months after diagnosis.
PG  - 1487-90
AB  - AIMS: The role of human leukocyte antigen (HLA) genes in the susceptibility to 
      Type 1 diabetes (T1DM) is well known. However, we do not know whether the degree 
      of pancreatic B-cell destruction depends on different HLA genetic risk. The aim 
      of this study was to analyse the influence of DRB1* and DQB1* genes on the rate 
      of pancreatic B-cell loss in a prospective series of 120 consecutive newly 
      diagnosed T1DM subjects in the first 12 months after diagnosis. METHODS: Patients 
      were typed for HLA-DRB1* and DQB1* loci by a reverse line blot assay using an 
      array of immobilized sequence-specific oligonucleotide probes. C-peptide, insulin 
      requirement and glycated haemoglobin (HbA(1c)) were determined at diagnosis and 
      every 3 months for 12 months. The variance of C-peptide as evidence of B-cell 
      loss during follow-up was analysed using the general linear model for 
      repeated-measures procedure. RESULTS: Fasting C-peptide in T1DM subjects with low 
      HLA genetic risk was significantly higher when compared with subjects with 
      moderate or high HLA genetic risk from time of diagnosis up to 12 months (P = 
      0.007 and P = 0.0002, respectively). Nonetheless, the changes in C-peptide levels 
      over a 12-month period did not differ significantly between T1DM subjects with 
      different HLA genetic risks. CONCLUSIONS: Low-risk HLA genotype in T1DM is 
      associated with less destruction of pancreatic B-cells up to 12 months after 
      diagnosis. These results are useful when designing trials for therapies aimed to 
      prevent the progression of B-cell destruction in recent-onset T1DM.
FAU - Spoletini, M
AU  - Spoletini M
AD  - Endocrinology, Department of Clinical Science, Sapienza University, Rome, Italy.
FAU - Petrone, A
AU  - Petrone A
FAU - Zampetti, S
AU  - Zampetti S
FAU - Capizzi, M
AU  - Capizzi M
FAU - Zavarella, S
AU  - Zavarella S
FAU - Osborn, J
AU  - Osborn J
FAU - Foffi, C
AU  - Foffi C
FAU - Tuccinardi, D
AU  - Tuccinardi D
FAU - Pozzilli, P
AU  - Pozzilli P
FAU - Buzzetti, R
AU  - Buzzetti R
CN  - IMDIAB Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071029
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - C-Peptide/*blood
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics/metabolism
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - Glycated Hemoglobin/analysis
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Insulin-Secreting Cells/*metabolism
MH  - Male
EDAT- 2007/11/01 09:00
MHDA- 2008/04/17 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/04/17 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - DME2292 [pii]
AID - 10.1111/j.1464-5491.2007.02292.x [doi]
PST - ppublish
SO  - Diabet Med. 2007 Dec;24(12):1487-90. doi: 10.1111/j.1464-5491.2007.02292.x. Epub 
      2007 Oct 29.