PMID- 17971357
OWN - NLM
STAT- MEDLINE
DCOM- 20080229
LR  - 20131121
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 16
IP  - 11
DP  - 2007
TI  - Hyperhomocysteinemia: a cardiovascular risk factor in autoimmune diseases?
PG  - 852-62
AB  - Epidemiological studies conducted over the past 25 years have provided ample 
      support for the association of mild hyperhomocysteinemia (HHcy) with an elevated 
      risk of atherothrombosis. Since autoimmune disorders (AD) are frequently 
      associated with relevant and early signs of atherothrombotic damage not 
      adequately explained by the traditional risk factors involved in the onset of 
      cardiovascular disease (CVD), a large interest has been shown to the putative 
      role of mild HHcy in this setting. On the basis of such considerations, we 
      focused the attention on the relationship between homocysteine (Hcy) and CVD in 
      patients affected with autoimmune diseases, reviewing the most recent literature 
      data and also providing our original experience. Although the large amount of 
      available studies clearly shows that HHcy represents a common finding in patients 
      affected with several autoimmune diseases, the actual role of Hcy in the 
      development of CVD in the course of AD is not clear yet, perhaps, with the only 
      exception of the systemic lupus erythematosus. In the other conditions, the role 
      of Hcy in the pathogenesis of vascular complications is still a matter of debate, 
      as the result of conflicting reports and/or lack of an adequate body of 
      investigation.
FAU - Lazzerini, P E
AU  - Lazzerini PE
AD  - Department of Clinical Medicine and Immunological Sciences, University of Siena, 
      Siena, Italy. pietroenea@yahoo.it
FAU - Capecchi, P L
AU  - Capecchi PL
FAU - Selvi, E
AU  - Selvi E
FAU - Lorenzini, S
AU  - Lorenzini S
FAU - Bisogno, S
AU  - Bisogno S
FAU - Galeazzi, M
AU  - Galeazzi M
FAU - Laghi Pasini, F
AU  - Laghi Pasini F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/epidemiology/*etiology/physiopathology
MH  - Autoimmune Diseases/*complications/physiopathology
MH  - Cross-Sectional Studies
MH  - Epidemiologic Research Design
MH  - Homocysteine/blood/*metabolism
MH  - Humans
MH  - Risk Factors
RF  - 83
EDAT- 2007/11/01 09:00
MHDA- 2008/03/01 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/03/01 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - 16/11/852 [pii]
AID - 10.1177/0961203307084176 [doi]
PST - ppublish
SO  - Lupus. 2007;16(11):852-62. doi: 10.1177/0961203307084176.