PMID- 17972088
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20210208
IS  - 0932-0067 (Print)
IS  - 0932-0067 (Linking)
VI  - 277
IP  - 5
DP  - 2008 May
TI  - Expression of insulin-like growth factor-1 receptors, Wilm's tumor-1 protein, 
      c-kit and p16 in primary fallopian tube carcinoma in diabetic patients.
PG  - 449-55
AB  - BACKGROUND: Primary fallopian tube carcinoma (PFTC) represents less than 1% of 
      all gynecological malignancies and its association with diabetes mellitus is 
      seldom reported. CASES: We report three cases of PFTC presented primarily as 
      advanced ovarian cancer while the primary site totally silent. Two of them were 
      diabetics and showed expression of insulin-like growth factor receptors, Wilm's 
      tumor protein-1, c-kit and P16. In all these cases there was neither clinical nor 
      perioperative suspicion of PFTC and the first clinical diagnosis was ovarian 
      carcinoma which was supported by positive cytology for ascitic fluid and raised 
      serum level of CA125. The diagnosis was only established after histopathologic 
      examination of serial sections of the whole fallopian tube since we were able to 
      demonstrate the continuity between the invasive and the in situ components of 
      PFTC in the lining epithelial layer of the fallopian tube. CONCLUSION: The 
      presence of malignant cells in the female pelvic organs without a mass should 
      raise the possibility of primary fallopian tube carcinoma. Pre-operative 
      diagnosis of PFTC is seldom made and most of the time the diagnosis is made after 
      histopathological examination as in our cases. Diabetes mellitus can be a risk 
      factor in the development of PFTC.
FAU - Al-Salam, Suhail
AU  - Al-Salam S
AD  - Department of Pathology, Faculty of Medicine and Health Sciences, United Arab 
      Emirates University, Al Ain, United Arab Emirates. suhsalam@yahoo.com
FAU - Alashari, Mouied
AU  - Alashari M
FAU - Ghazal-Aswad, Saad
AU  - Ghazal-Aswad S
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20071031
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (WT1 Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma/complications/*metabolism/pathology
MH  - Cyclin-Dependent Kinase Inhibitor p16
MH  - Diabetes Complications/complications/metabolism/pathology
MH  - Fallopian Tube Neoplasms/complications/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-kit/*metabolism
MH  - Receptor, IGF Type 1/*metabolism
MH  - WT1 Proteins/*metabolism
EDAT- 2007/11/01 09:00
MHDA- 2008/10/10 09:00
CRDT- 2007/11/01 09:00
PHST- 2007/07/16 00:00 [received]
PHST- 2007/10/15 00:00 [accepted]
PHST- 2007/11/01 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2007/11/01 09:00 [entrez]
AID - 10.1007/s00404-007-0494-2 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2008 May;277(5):449-55. doi: 10.1007/s00404-007-0494-2. Epub 
      2007 Oct 31.