PMID- 17972890
OWN - NLM
STAT- MEDLINE
DCOM- 20080304
LR  - 20071231
IS  - 0743-8346 (Print)
IS  - 0743-8346 (Linking)
VI  - 28
IP  - 1
DP  - 2008 Jan
TI  - The erythrocyte indices of neonates, defined using data from over 12,000 patients 
      in a multihospital health care system.
PG  - 24-8
AB  - OBJECTIVE: The erythrocyte indices (mean corpuscular volume (MCV), mean 
      corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin 
      (MCH)) were originally reported using hand-calculated values, based on a 
      centrifuge-spun hematocrit, a counting-chamber erythrocyte count and a hemoglobin 
      concentration measured by any number of hemoglobinometry methods. Modern blood 
      cell analyzers measure the MCV, and calculate the MCHC and MCH, on the basis of 
      logs higher sample sizes than employed in the original methods. STUDY DESIGN: 
      With a single type of automated blood cell counter (Beckman Coulter LH 750; 
      Fullerton, CA, USA), we determined the ranges of erythrocyte indices among 
      neonates of 22 to 42 weeks gestation. Data were accumulated during a 3-year 
      period from a multihospital health care system, using all indices reported on 
      untransfused neonates during their first day of life. RESULT: Erythrocyte indices 
      were obtained from 17,634 tests performed on 12,016 neonates. The MCV and the MCH 
      decreased with advancing gestational age. For instance, the MCV diminished from 
      119+/-7 fl (mean+/-s.d.) in neonates < or =25 weeks gestation to 106+/-4 fl at 40 
      weeks. The MCH diminished from 40+/-2 pg in neonates < or =25 weeks gestation to 
      36+/-2 pg at 40 weeks. The MCHC did not change appreciably with gestational age 
      (34+/-1 pg dl(-1)). CONCLUSION: The results describe the expected values for 
      erythrocyte indices on the first day of life among untransfused neonates. 
      Additional study is needed to determine the relevance of very high or low 
      erythrocyte indices in this population and to understand any physiological 
      advantage of these very large erythrocytes during fetal development.
FAU - Christensen, R D
AU  - Christensen RD
AD  - Intermountain Healthcare, Ogden, UT 84403, USA. rdchris@ihc.com
FAU - Jopling, J
AU  - Jopling J
FAU - Henry, E
AU  - Henry E
FAU - Wiedmeier, S E
AU  - Wiedmeier SE
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20071101
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
SB  - IM
MH  - Databases, Factual
MH  - Erythrocyte Indices/*physiology
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Reference Values
MH  - Retrospective Studies
EDAT- 2007/11/02 09:00
MHDA- 2008/03/05 09:00
CRDT- 2007/11/02 09:00
PHST- 2007/11/02 09:00 [pubmed]
PHST- 2008/03/05 09:00 [medline]
PHST- 2007/11/02 09:00 [entrez]
AID - 7211852 [pii]
AID - 10.1038/sj.jp.7211852 [doi]
PST - ppublish
SO  - J Perinatol. 2008 Jan;28(1):24-8. doi: 10.1038/sj.jp.7211852. Epub 2007 Nov 1.