PMID- 17973869
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20220321
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 34
IP  - 12
DP  - 2007 Dec
TI  - Associations between 45T/G polymorphism of the adiponectin gene and plasma 
      adiponectin levels with type 2 diabetes.
PG  - 1287-90
AB  - 1. The purpose of the present study was to investigate the association between 
      the single nucleotide polymorphism (SNP) 45T/G and plasma adiponectin levels and 
      the prevalence of Type 2 diabetes mellitus (T2DM) in Uygurs of the Xinjiang 
      region, China. 2. We performed a cross-sectional survey in a representative 
      sample of 151 Uygur adults aged 24-80 years. The polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to 
      determine the distribution of allele and genotype frequency of the SNP45 T/G 
      polymorphism (exon 2) in the adiponectin gene. An ELISA was used to determine 
      plasma adiponectin levels. Logistic regression was used to screen risk factors 
      for T2DM. 3. Compared with the normal glucose tolerance (NGT) group, the T2DM 
      group exhibited a higher distribution of the TG + GG genotype, G allele frequency 
      and lower plasma adiponectin concentrations in TG + GG genotype carriers compared 
      with those with the TT genotype. Compared with SNP45 T carriers, in the NGT 
      group, G carriers had higher levels of systolic and diastolic blood pressure, low 
      density lipoprotein (P < 0.05) and total cholesterol (P < 0.005). In the T2DM 
      group, G carriers had lower levels of homeostasis model assessment (HOMA) of 
      insulin sensitivity (P < 0.05) and higher levels of HOMA of insulin resistance (P 
      < 0.05). 4. Adiponectin SNP 45 is positively correlated with the prevalence of 
      T2DM in Uygurs of Xinjiang. The G allele carriers who have reduced plasma 
      concentrations of adiponectin may have associated insulin resistance.
FAU - Li, Lin-Lin
AU  - Li LL
AD  - Department of Pharmacology, Xinjiang Medical University, Urumuqi, China.
FAU - Kang, Xiao-Long
AU  - Kang XL
FAU - Ran, Xin-Jian
AU  - Ran XJ
FAU - Wang, Ye
AU  - Wang Y
FAU - Wang, Chang-Hui
AU  - Wang CH
FAU - Huang, Lin
AU  - Huang L
FAU - Ren, Jun
AU  - Ren J
FAU - Luo, Xin
AU  - Luo X
FAU - Mao, Xin-Min
AU  - Mao XM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/blood/*genetics
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
EDAT- 2007/11/02 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/11/02 09:00
PHST- 2007/11/02 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/11/02 09:00 [entrez]
AID - CEP4713 [pii]
AID - 10.1111/j.1440-1681.2007.04713.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2007 Dec;34(12):1287-90. doi: 
      10.1111/j.1440-1681.2007.04713.x.