PMID- 17976097
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20071102
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30
IP  - 11
DP  - 2007 Nov
TI  - The impact of age and gender on cardiac resynchronization therapy outcome.
PG  - 1344-8
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) outcome varies significantly 
      among patients. We aimed to determine the impact of age, gender, and heart 
      failure etiology on the long-term outcome of patients receiving CRT. METHODS: A 
      total of 117 patients with drug-refractory heart failure, New York Heart 
      Association (NYHA) Class III or IV, and a wide QRS complex, who received CRT, 
      were followed for one year. Long-term outcome was measured as a combined end 
      point of hospitalization for heart failure and/or all cause mortality. Efficacy 
      of CRT was compared between men and women, between older and younger patients, 
      and between patients with ischemic and nonischemic heart disease. Time to the 
      primary end point was estimated by the Kaplan-Meier method and comparisons were 
      made using the Breslow-Wilcoxon test. RESULTS: Baseline clinical characteristics 
      were comparable between gender, age, and heart failure etiology subgroups. There 
      was no significant difference in the combined end point between older versus 
      younger (age >70, (n = 71), versus age < 70, (n = 46), P = 0.52); both genders 
      (men, n = 91 vs women, n = 26, P = 0.46) and etiology of the cardiomyopathy 
      (ischemic (n = 79) vs nonischemic (n = 38), P = 0.12). Substratification of the 
      genders by the etiology of the cardiomyopathy, showed that women with ischemic 
      cardiomyopathy (IW, n = 10) had a trend to a worse outcome compared to the other 
      groups i.e., nonischemic women (NIW, n = 16), ischemic men (IM, n = 69), and 
      nonischemic men (NIM, n = 22), P = 0.04. After adjusting for potential 
      covariates, a Cox regression analysis showed no significant difference between 
      the groups (P = 0.61). CONCLUSIONS: CRT outcome appears independent of age, 
      gender, and heart failure etiology in this single institution study.
FAU - Zardkoohi, Omeed
AU  - Zardkoohi O
AD  - Cardiac Arrhythmia Service, Department of Medicine, Massachusetts General 
      Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
FAU - Nandigam, Veena
AU  - Nandigam V
FAU - Murray, Lorne
AU  - Murray L
FAU - Heist, E Kevin
AU  - Heist EK
FAU - Mela, Theofanie
AU  - Mela T
FAU - Orencole, Mary
AU  - Orencole M
FAU - Ruskin, Jeremy N
AU  - Ruskin JN
FAU - Singh, Jagmeet P
AU  - Singh JP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Age Distribution
MH  - Aged
MH  - Cardiac Output, Low/*epidemiology/*prevention & control
MH  - Cardiac Pacing, Artificial/*statistics & numerical data
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Male
MH  - Massachusetts/epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Sex Distribution
MH  - Treatment Outcome
EDAT- 2007/11/03 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/11/03 09:00
PHST- 2007/11/03 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/11/03 09:00 [entrez]
AID - PACE869 [pii]
AID - 10.1111/j.1540-8159.2007.00869.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Nov;30(11):1344-8. doi: 
      10.1111/j.1540-8159.2007.00869.x.