PMID- 17976100
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20071102
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30
IP  - 11
DP  - 2007 Nov
TI  - Cardiac resynchronization therapy response is associated with shorter duration of 
      atrial fibrillation.
PG  - 1363-8
AB  - BACKGROUND: Atrial fibrillation (AF) is commonly associated with heart failure. 
      The benefit of cardiac resynchronization therapy (CRT) on atrial remodeling has 
      been demonstrated. However, biventricular pacing did not reduce the global 
      incidence of AF. We evaluated the relationship between CRT response and AF 
      duration. METHODS: We retrospectively analyzed data from 96 patients (59 +/- 15 
      years; 78% male) who underwent CRT. All patients had class III-IV New York Heart 
      Association (NYHA) symptoms despite maximal medical therapy, left ventricular 
      ejection fraction (LVEF) < or = 35%, QRS >130 ms, and sinus rhythm before 
      implantation. CRT response in patients who survived at six months of follow-up 
      was defined as: (1) no hospitalization for heart failure and (2) improvement of 
      one or more grades in the NYHA classification. RESULTS: CRT responders (n = 54) 
      and non-responders (n = 42) had similar baseline characteristics, including the 
      incidence of persistent AF within six months before implantation. Six months 
      after implantation, when compared to baseline, CRT responders exhibited a 
      significant decrease in left atrial size (47.5 +/- 7.1 mm vs 44.6 +/- 7.7 mm, P < 
      0.01) and in the incidence of persistent AF (17% vs 2%, P = 0.02). At six months, 
      CRT responders demonstrated shorter mean AF duration (7.5 +/- 43.3 hours vs 48.8 
      +/- 129.0 hours, P = 0.03) and lower incidence of persistent AF (2% vs 19%, P = 
      0.004) compared to nonresponders. CONCLUSION: CRT response is associated with a 
      reversal of atrial remodeling and a shorter AF duration.
FAU - Lellouche, Nicolas
AU  - Lellouche N
AD  - UCLA Cardiac Arrhythmia Center, Division of Cardiology, Department of Medicine, 
      David Geffen School of Medicine at UCLA, University of California-Los Angeles, 
      10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
FAU - De Diego, Carlos
AU  - De Diego C
FAU - Vaseghi, Marmar
AU  - Vaseghi M
FAU - Buch, Eric
AU  - Buch E
FAU - Cesario, David A
AU  - Cesario DA
FAU - Mahajan, Aman
AU  - Mahajan A
FAU - Wiener, Isaac
AU  - Wiener I
FAU - Fonarow, Gregg C
AU  - Fonarow GC
FAU - Boyle, Noel G
AU  - Boyle NG
FAU - Shivkumar, Kalyanam
AU  - Shivkumar K
LA  - eng
GR  - R01 HL 084261/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Atrial Fibrillation/*diagnosis/*prevention & control
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2007/11/03 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/11/03 09:00
PHST- 2007/11/03 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/11/03 09:00 [entrez]
AID - PACE872 [pii]
AID - 10.1111/j.1540-8159.2007.00872.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Nov;30(11):1363-8. doi: 
      10.1111/j.1540-8159.2007.00872.x.