PMID- 17976248
OWN - NLM
STAT- MEDLINE
DCOM- 20071203
LR  - 20081121
IS  - 1462-3994 (Electronic)
IS  - 1462-3994 (Linking)
VI  - 9
IP  - 29
DP  - 2007 Nov 2
TI  - Haematopoietic stem cell transplantation: can our genes predict clinical outcome?
PG  - 1-19
AB  - Haematopoietic stem cell transplantation (HSCT) is currently the only curative 
      treatment for many patients with malignant and non-malignant haematological 
      diseases. The success of HSCT is greatly reduced by the development of 
      complications, which include graft-versus-host disease (GVHD), relapse and 
      infection. Human leukocyte antigen (HLA) matching of patients and donors is 
      essential, but does not completely prevent these complications; non-HLA genes may 
      also have an impact upon transplant outcome. Polymorphisms within genes that are 
      associated with an individual's capability to mount an immune response to 
      alloantigen and infectious pathogens and/or response to drugs (pharmacogenomics) 
      are all currently being studied for their association with HSCT outcome. This 
      review summarises the potential role of non-HLA polymorphisms in predicting HSCT 
      outcome, from studies on retrospective transplant cohorts of HLA-identical 
      siblings and matched unrelated donors. The clinical relevance and interpretation 
      of non-HLA genetics, and how these could be used alongside clinical risk factors 
      in HSCT, are also discussed.
FAU - Dickinson, Anne M
AU  - Dickinson AM
AD  - School of Clinical and Laboratory Sciences, Institute of Cellular Medicine, 
      Newcastle University Medical School, Newcastle upon Tyne, UK. 
      a.m.dickinson@ncl.ac.uk
FAU - Harrold, Jane L
AU  - Harrold JL
FAU - Cullup, Hannah
AU  - Cullup H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071102
PL  - England
TA  - Expert Rev Mol Med
JT  - Expert reviews in molecular medicine
JID - 100939725
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
SB  - IM
MH  - Animals
MH  - Chemokines/genetics/immunology
MH  - Cohort Studies
MH  - Cytokines/genetics/immunology
MH  - Donor Selection
MH  - Genotype
MH  - *Graft vs Host Disease/genetics/therapy
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunity, Innate/physiology
MH  - Pharmacogenetics
MH  - *Polymorphism, Genetic
MH  - Receptors, Chemokine/genetics/immunology
MH  - Receptors, Cytokine/genetics/immunology
MH  - Retrospective Studies
MH  - Transplantation Conditioning
MH  - Treatment Outcome
RF  - 129
EDAT- 2007/11/03 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/11/03 09:00
PHST- 2007/11/03 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/11/03 09:00 [entrez]
AID - S1462399407000488 [pii]
AID - 10.1017/S1462399407000488 [doi]
PST - epublish
SO  - Expert Rev Mol Med. 2007 Nov 2;9(29):1-19. doi: 10.1017/S1462399407000488.