PMID- 17976312
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20071102
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 4
IP  - 5
DP  - 2007 Oct
TI  - The dual effects of interleukin-18 in tumor progression.
PG  - 329-35
AB  - Interleukin-18 (IL-18) was discovered as an interferon-gamma-inducing factor and 
      had a critical role in inflammatory and immune response. It stimulates natural 
      killer (NK) and T cells and enhances Th1 immune response. These activated immune 
      cells eliminate cancer cells and virus-infected cells effectively. However, IL-18 
      has also been found to promote tumor progression. Higher expression or secretion 
      level of IL-18 is detected in various cancer cells in comparison with normal 
      control, and IL-18 is able to induce angiogenesis, migration/metastasis, 
      proliferation and immune escape. These dual effects and the mechanism of IL-18 
      need to be investigated further as it relates to cancer.
FAU - Park, Sunyoung
AU  - Park S
AD  - Department of Life Science, Sookmyung Women's University, Chungpa-Dong 2-Ka, 
      Yongsan-Ku, Seoul 140-742, Korea.
FAU - Cheon, Soyoung
AU  - Cheon S
FAU - Cho, Daeho
AU  - Cho D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - Cytokines/immunology/metabolism
MH  - Disease Progression
MH  - Humans
MH  - Interleukin-18/*immunology/metabolism
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Lymphocyte Activation
MH  - Neoplasm Metastasis
MH  - Neoplasms/blood supply/*immunology/pathology/therapy
MH  - Neovascularization, Pathologic
MH  - T-Lymphocytes/immunology/metabolism
MH  - Th2 Cells/*immunology/metabolism
MH  - Tumor Escape/immunology
RF  - 64
EDAT- 2007/11/03 09:00
MHDA- 2008/02/20 09:00
CRDT- 2007/11/03 09:00
PHST- 2007/11/03 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/11/03 09:00 [entrez]
PST - ppublish
SO  - Cell Mol Immunol. 2007 Oct;4(5):329-35.