PMID- 17979705
OWN - NLM
STAT- MEDLINE
DCOM- 20071128
LR  - 20220408
IS  - 0929-8673 (Print)
IS  - 0929-8673 (Linking)
VI  - 14
IP  - 24
DP  - 2007
TI  - Viral origins of human cancer.
PG  - 2526-39
AB  - The first consistent observations that viruses could be associated with some 
      types of cancer where made almost a century ago. Since then researchers have 
      spent a great deal of effort to address the infectious origins of human cancer. 
      As a result of these studies, a strong link between some viral agents and several 
      human cancers has been established. Some viruses as the Epstein-Barr virus (EBV), 
      hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell lymphotropic virus 
      type I (HTLV-I), immunodeficiency virus type I (HIV-I) and several human 
      papillomavirus types (including types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 
      59 and 66) have been classified as group 1 carcinogens by the International 
      Agency for Research in Cancer (IARC). Infection by these viruses constitutes a 
      heavy burden for human populations as it accounts for almost 15% of all human 
      malignancies. Furthermore, many other viral agents have been classified as 
      possibly carcinogenic to humans and others have been occasionally found in human 
      tumors suggesting that this figure may be an underestimation of virus involvement 
      in the etiology of human cancer. Therefore, viral infection appears as one of the 
      main preventable cancer risk factors. We summarize the current state of knowledge 
      concerning virus-induced/associated cancers and discuss its significance in the 
      context of human carcinogenesis. Prevention and control of infection by these 
      agents could dramatically reduce the incidence of some prevalent cancers and, 
      consequently, have a great impact on public health.
FAU - Boccardo, E
AU  - Boccardo E
AD  - Laboratory of Virology, Ludwig Institute for Cancer Research, Sao Paulo Branch. 
      Rua Joao Juliao 245, 01323-930 Sao Paulo, SP, Brazil. eboccardo@ludwig.org.br
FAU - Villa, L L
AU  - Villa LL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Neoplasms/*etiology/genetics/pathology/*virology
MH  - Oncogene Proteins/genetics/metabolism
MH  - Virus Diseases/*complications/genetics/pathology/*virology
RF  - 345
EDAT- 2007/11/06 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/11/06 09:00
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
AID - 10.2174/092986707782023316 [doi]
PST - ppublish
SO  - Curr Med Chem. 2007;14(24):2526-39. doi: 10.2174/092986707782023316.