PMID- 17980409
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20181201
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 90
IP  - 2
DP  - 2008 Aug
TI  - Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT 
      transporter expression and function: studies in adult mice hippocampus.
PG  - 174-83
AB  - In vivo intracerebral microdialysis is an important neurochemical technique that 
      has been applied extensively in genetic and pharmacological studies aimed at 
      investigating the relationship between neurotransmitters. Among the main 
      interests of microdialysis application is the infusion of drugs through the 
      microdialysis probe (reverse dialysis) in awake, freely moving animals. As an 
      example of the relevance of intracerebral microdialysis, this review will focus 
      on our recent neurochemical results showing the impact of Brain-Derived 
      Neurotrophic Factor (BDNF) on serotonergic neurotransmission in basal and 
      stimulated conditions. Indeed, although the elevation of 5-HT outflow induced by 
      chronic administration of selective serotonin reuptake inhibitors (SSRIs) causes 
      an increase in BDNF protein levels and expression (mRNA) in the hippocampus of 
      rodents, the reciprocal interaction has not been demonstrated yet. Thus, the 
      neurochemical sight of this question will be addressed here by examining the 
      consequences of either a constitutive decrease or increase in brain BDNF protein 
      levels on hippocampal extracellular levels of 5-HT in conscious mice.
FAU - Deltheil, Thierry
AU  - Deltheil T
AD  - Univ. Paris Sud, EA 3544, Fac. Pharmacie, Chatenay-Malabry cedex F-92296, France.
FAU - Guiard, Bruno P
AU  - Guiard BP
FAU - Guilloux, Jean-Philippe
AU  - Guilloux JP
FAU - Nicolas, Lorelei
AU  - Nicolas L
FAU - Delomenie, Claudine
AU  - Delomenie C
FAU - Reperant, Christelle
AU  - Reperant C
FAU - Le Maitre, Erwan
AU  - Le Maitre E
FAU - Leroux-Nicollet, Isabelle
AU  - Leroux-Nicollet I
FAU - Benmansour, Saloua
AU  - Benmansour S
FAU - Coudore, Francois
AU  - Coudore F
FAU - David, Denis J
AU  - David DJ
FAU - Gardier, Alain M
AU  - Gardier AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071003
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - Citalopram/metabolism
MH  - Hippocampus/*metabolism
MH  - Mice
MH  - Microdialysis/*methods
MH  - Paroxetine/pharmacology
MH  - RNA, Messenger/analysis
MH  - Serotonin/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics/physiology
RF  - 41
EDAT- 2007/11/06 09:00
MHDA- 2008/08/13 09:00
CRDT- 2007/11/06 09:00
PHST- 2007/06/28 00:00 [received]
PHST- 2007/09/19 00:00 [revised]
PHST- 2007/09/27 00:00 [accepted]
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
AID - S0091-3057(07)00310-3 [pii]
AID - 10.1016/j.pbb.2007.09.018 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2008 Aug;90(2):174-83. doi: 10.1016/j.pbb.2007.09.018. 
      Epub 2007 Oct 3.