PMID- 17980921
OWN - NLM
STAT- MEDLINE
DCOM- 20080407
LR  - 20131121
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 187
IP  - 2
DP  - 2008 Mar 5
TI  - Environmental prenatal stress alters sexual dimorphism of maternal behavior in 
      rats.
PG  - 284-8
AB  - The prenatal external environment can affect fetuses, altering the maternal 
      behavior that they express when mature. In the present study, environmental 
      prenatal stress (EPS) was applied to pregnant rats in their final week of 
      gestation, and when their female offspring reached maturity, the long latency 
      effect of the stress on those offspring was ascertained on their induced maternal 
      behavior (MB), accessory olfactory bulb (AOB) morphology and plasma levels of 
      ACTH and corticosterone (Cpd B). EPS reduced: the percentage of these virgins 
      that showed induced MB, their retrieval of foster pups, the time spent crouching, 
      and the quality of nest building; it also increased the incidence of their 
      cannibalism of foster pups. The EPS-treated females presented a male-like pattern 
      of induced MB. They showed increased plasma levels of ACTH and Cpd B and 
      increased numbers of mitral cells in the AOB. These findings provide evidence 
      that stress applied to the pregnant rat produces long-lasting behavioral, 
      neuroanatomical and hormonal alterations in the female offspring that can be 
      observed when they reach maturity.
FAU - Perez-Laso, Carmen
AU  - Perez-Laso C
AD  - Departamento de Psicobiologia, Universidad Nacional de Educacion a Distancia, 
      c/Juan del Rosal, 10, 28040 Madrid, Spain.
FAU - Segovia, Santiago
AU  - Segovia S
FAU - Martin, Jose Luis R
AU  - Martin JL
FAU - Ortega, Esperanza
AU  - Ortega E
FAU - Gomez, Francisco
AU  - Gomez F
FAU - Del Cerro, M Cruz R
AU  - Del Cerro MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070929
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Analysis of Variance
MH  - Animals
MH  - Corticosterone/blood
MH  - Environment
MH  - Female
MH  - Male
MH  - *Maternal Behavior
MH  - Nesting Behavior
MH  - Neurons/cytology
MH  - Olfactory Bulb/*cytology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Statistics, Nonparametric
MH  - Stress, Psychological/*blood
EDAT- 2007/11/06 09:00
MHDA- 2008/04/09 09:00
CRDT- 2007/11/06 09:00
PHST- 2007/01/12 00:00 [received]
PHST- 2007/07/06 00:00 [revised]
PHST- 2007/09/18 00:00 [accepted]
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
AID - S0166-4328(07)00496-2 [pii]
AID - 10.1016/j.bbr.2007.09.029 [doi]
PST - ppublish
SO  - Behav Brain Res. 2008 Mar 5;187(2):284-8. doi: 10.1016/j.bbr.2007.09.029. Epub 
      2007 Sep 29.