PMID- 17981743
OWN - NLM
STAT- MEDLINE
DCOM- 20071211
LR  - 20190902
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 13
DP  - 2008 Jan 1
TI  - Pathogenic role of CCL2/MCP-1 in scleroderma.
PG  - 2686-95
AB  - Scleroderma is a connective tissue disease with unknown etiology characterized by 
      excessive deposition of extracellular matrix in the skin. Cellular infiltrates of 
      certain immune cells and proinflammatory mediators are suggested to play a 
      crucial role in cutaneous fibrosis, forming complicated networks between 
      fibroblasts and immune cells via cell-cell communications. Tissue-selective 
      trafficking of leukocytes is mediated by combinations of adhesion molecules and 
      chemokines. Recent studies have shown that an increase in proinflammatory 
      chemokines has been associated with the initiation and/or development of fibrotic 
      condition, suggesting that chemokines and their receptors may be important 
      mediators of inflammation and fibrosis in scleroderma. In particular, 
      CCL2/monocyte chemoattractant protein-1 (MCP-1) has been suggested to play an 
      important role in scleroderma. This review will focus on the roles of CCL2 and 
      its receptor during the process of cutaneous sclerosis, and also provide a 
      current insight into the potential mechanisms of scleroderma.
FAU - Yamamoto, Toshiyuki
AU  - Yamamoto T
AD  - Department of Dermatology, Fukushima Medical University, Fukushima, Japan. 
      toyamade@fmu.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080101
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Animals
MH  - Cell Adhesion
MH  - Cell Adhesion Molecules/metabolism
MH  - Chemokine CCL2/*physiology
MH  - Chemokines/metabolism
MH  - Extracellular Matrix/metabolism
MH  - Fibroblasts/metabolism
MH  - Fibrosis
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Inflammation
MH  - Leukocytes/metabolism
MH  - Receptors, Chemokine/metabolism
MH  - Scleroderma, Systemic/*metabolism
MH  - Skin Diseases/metabolism
RF  - 122
EDAT- 2007/11/06 09:00
MHDA- 2007/12/12 09:00
CRDT- 2007/11/06 09:00
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2007/12/12 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
AID - 2875 [pii]
AID - 10.2741/2875 [doi]
PST - epublish
SO  - Front Biosci. 2008 Jan 1;13:2686-95. doi: 10.2741/2875.