PMID- 17982227
OWN - NLM
STAT- MEDLINE
DCOM- 20080110
LR  - 20211020
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 22
IP  - 5
DP  - 2007 Oct
TI  - Association of polymorphisms in monocyte chemoattractant protein-1 promoter with 
      diabetic kidney failure in Korean patients with type 2 diabetes mellitus.
PG  - 810-4
AB  - Monocyte chemoattractant protein-1 (MCP-1) is suggested to be involved in the 
      progression of diabetic nephropathy. We investigated the association of the -2518 
      A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean 
      patients with type 2 diabetes mellitus (DM). We investigated -2518 A/G 
      polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney 
      failure (n=112) compared with matched type 2 DM patients without nephropathy 
      (diabetic control, n=112) and healthy controls (n=230). The overall genotypic 
      distribution of -2518 A/G in the MCP-1 gene was not different in patients with 
      type 2 DM compared to healthy controls. Although the genotype was not 
      significantly different between the patients with kidney failure and the diabetic 
      control (p=0.07), the A allele was more frequent in patients with kidney failure 
      than in DM controls (42.0 vs. 32.1%, p=0.03). The carriage of A allele was 
      significantly associated with kidney failure (68.8 vs. 54.5%, OR 1.84, 95% CI 
      1.07-3.18). In logistic regression analysis, carriage of A allele retained a 
      significant association with diabetic kidney failure. Our result shows that the 
      -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean 
      patients with type 2 DM.
FAU - Moon, Ju-young
AU  - Moon JY
AD  - Department of Nephrology, College of Medicine, Kyunghee University, Seoul, Korea.
FAU - Jeong, Laeik
AU  - Jeong L
FAU - Lee, Sangho
AU  - Lee S
FAU - Jeong, Kyunghwan
AU  - Jeong K
FAU - Lee, Taewon
AU  - Lee T
FAU - Ihm, Chun-Gyoo
AU  - Ihm CG
FAU - Suh, Jungho
AU  - Suh J
FAU - Kim, Junghee
AU  - Kim J
FAU - Jung, Yoo-yeon
AU  - Jung YY
FAU - Chung, Joo-Ho
AU  - Chung JH
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Chemokine CCL2/*metabolism
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics/*metabolism
MH  - Diabetic Nephropathies/ethnology/*genetics/*metabolism
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Renal Insufficiency
MH  - Risk Factors
PMC - PMC2693845
EDAT- 2007/11/06 09:00
MHDA- 2008/01/11 09:00
PMCR- 2007/10/01
CRDT- 2007/11/06 09:00
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2008/01/11 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
PHST- 2007/10/01 00:00 [pmc-release]
AID - 200710810 [pii]
AID - 10.3346/jkms.2007.22.5.810 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2007 Oct;22(5):810-4. doi: 10.3346/jkms.2007.22.5.810.